Regulation of Insulin-Like Growth Factor-I by Nutrition

  • Jean-Paul Thissen
  • Véronique Beauloye
  • Jean-Marie Ketelslegers
  • Louis E. Underwood
Part of the Nutrition and Health book series (NH)


  • Nutrition is one of the principal regulators of circulating IGF-I. Many mechanisms are involved in the nutritional regulation of IGF-I.

  • Both energy and protein are critical to the regulation of serum IGF-I concentrations. After fasting, adequate energy and protein are necessary for restoration of serum IGF-I, but energy may be somewhat more important than protein. While a low intake of protein is able to increase IGF-I in the presence of adequate energy, there is a threshold requirement of energy below which optimal protein intake fails to raise IGF-I after fasting.

  • The decline of serum IGF-I during dietary restriction is independent of diet-induced alterations in pituitary GH secretion. In severe dietary restriction (fasting), a marked decrease in the number of liver somatogenic receptors suggests that a GH receptor defect is involved in the decline of serum IGF-I. In protein restriction, the decline of serum IGF-I results from a postreceptor defect in GH action at the hepatic level.

  • Nutritional deprivation decreases hepatic IGF-I production by diminishing IGF-I gene expression. Decline in IGF-I gene expression results from both transcriptional and post-transcription mechanisms.

  • Diet restriction also increases the clearance and degradation of serum IGF-I through changes in the levels of circulating IGFBPs.

  • The molecular mechanisms leading to the decline of IGF-I in catabolic stress seem to be similar to those operational in food deprivation.

  • Nutrients may also control the biological action of IGF-I, either directly or indirectly, through changes in IGFBPs.


Growth Hormone Growth Hormone Receptor Amino Acid Deprivation Acid Labile Subunit Dietary Protein Restriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Jean-Paul Thissen
  • Véronique Beauloye
  • Jean-Marie Ketelslegers
  • Louis E. Underwood

There are no affiliations available

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