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Mechanisms of Cardiac Hypertrophy and the Development of Heart Failure

Role of Insulin-Like Growth Factor-I and Angiotensin-II

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Book cover IGF and Nutrition in Health and Disease

Part of the book series: Nutrition and Health ((NH))

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Abstract

  • The RAS and the IGF-I system interact at multiple levels to regulate physiological and pathological cardiac growth responses.

  • IGF-I promotes growth and survival of cardiac and skeletal muscle which is salutary in heart failure.

  • AngII down regulates circulating and skeletal muscle IGF-I and IGF binding proteins, leading to increased myocardial apoptosis and increased skeletal muscle proteolysis.

  • Preliminary studies reveal significant alterations in the IGF-I system in heart failure.

  • An imbalance between the RAS and the IGF-I system contributes to the progression from compensated to decompensated heart failure.

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Authors
  1. Patrice Delafontaine
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  2. Marijke Brink
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  3. Yao-Hua Song
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Editor information

Editors and Affiliations

  1. Food and Nutrition Program, School of Family and Consumer, Bowling Green State University, Bowling Green, OH, USA

    M. Sue Houston PhD, RD

  2. Division of Surgery, Department of Hospital Medicine, Bristol Royal Infirmary, Bristol, UK

    Jeffrey M. P. Holly PhD

  3. JDRF Center for the Study of Complications in Diabetes, Department of Neurology, University of Michigan, Ann Arbor, MI, USA

    Eva L. Feldman MD, PhD

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Delafontaine, P., Brink, M., Song, YH. (2004). Mechanisms of Cardiac Hypertrophy and the Development of Heart Failure. In: Houston, M.S., Holly, J.M.P., Feldman, E.L. (eds) IGF and Nutrition in Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-795-6_17

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  • DOI: https://doi.org/10.1007/978-1-59259-795-6_17

  • Publisher Name: Humana Press, Totowa, NJ

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