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Cancer Diagnostics pp 307–321Cite as

A Marker for Early Diagnosis of Lung Cancer

The Heterogeneous Nuclear Ribonucleoprotein A2/B1 (hnRNP A2/B1)

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Part of the book series: Contemporary Cancer Research ((CCR))

Abstract

Lung cancer is the most important leading cause of cancer death. In the United States alone, 169,000 new cases were identified in 2002 (1) and lung cancer is responsible for more than 1 million deaths worldwide (2). Lung cancer has a lower incidence than other types of cancer (breast, colon, prostate, and cervical) but is more lethal. Throughout most of the world, 5-yr survival is less than 10%. Even with smoking cessation, the risk of lung cancer remains elevated because the injury in the airway tissue cannot be reversed (3). One of the reasons for such high mortality is the late detection of lung cancer, which in most cases occurs after metastatic dissemination. In those cases, the benefits of chemotherapy are modest. The classical diagnostic imaging technology, chest X-ray, is not sensitive enough to provide a reliable early diagnosis of lung cancer. One approach to improve early detection is looking for specific molecular markers that may be tools for a better understanding of the initial steps of carcinogenesis.

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Authors
  1. Jordi Tauler
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  2. Alfredo Martínez
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  3. James L. Mulshine
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Editors and Affiliations

  1. Scripps Clinic, La Jolla, CA, USA

    Robert M. Nakamura MD

  2. UCLA School of Medicine, Los Angeles, CA, USA

    Wayne W. Grody MD, PhD

  3. ARUP Labs, Salt Lake City, UT, USA

    James T. Wu PhD

  4. Arizona Cancer Center, Tucson, AZ, USA

    Raymond B. Nagle MD, PhD

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© 2004 Springer Science+Business Media New York

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Tauler, J., Martínez, A., Mulshine, J.L. (2004). A Marker for Early Diagnosis of Lung Cancer. In: Nakamura, R.M., Grody, W.W., Wu, J.T., Nagle, R.B. (eds) Cancer Diagnostics. Contemporary Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-791-8_15

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  • DOI: https://doi.org/10.1007/978-1-59259-791-8_15

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