Malaria And Immunity

  • Clara Menéndez
  • Carlota Dobaňo


Pregnant Woman Malaria Infection Severe Malaria Cerebral Malaria Entomological Inoculation Rate 
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  1. 1.
    Verhoef, H., West, C.E., Veneemans, J., Beguin, Y., and Kok, F.J. (2002) Stunting may determine the severity of malaria-associated anemia in African children. Pediatrics 110, 48–52.CrossRefGoogle Scholar
  2. 2.
    Bradley-Moore, A.M., Greenwood, B.M., and Bradley, A.K. (1985) Malaria chemoprophylaxis with chloroquine in young Nigerian children. III. Its effect on nutrition. Ann. Trop. Med. Parasitol. 79, 575–584.Google Scholar
  3. 3.
    Hendrickse, R.G., Hasan, A.H., Olumide, L.O., and Akinkunmi, A. (1971) Malaria in early childhood. An investigation of five hundred seriously ill children in whom a “clinical” diagnosis of malaria was made on admission to the children’s emergency room at University College Hospital, Ibadan. Ann. Trop. Med. Parasitol. 65, 1–20.Google Scholar
  4. 4.
    World Health Organization Expert Committee on Malaria. (2000) Twentieth Report, WHO Tech. Rep. Ser. 892, WHO, Geneva.Google Scholar
  5. 5.
    Borst, P., Bitter, W., Mcculloch, R., Vanleeuwen, F., and Rudenko, G. (1985) Antigen variation in malaria. Cell 82, 1–4.CrossRefGoogle Scholar
  6. 6.
    Bickle, A., Anders, R.F., Day, K., and Coppel, R.L. (1993) The S-antigen of Plasmodium falciparum: repertoire and origin of diversity. Mol. Biochern. Parasitol. 61, 189–196.CrossRefGoogle Scholar
  7. 7.
    Brown, K. and Brown, N. (1965) Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature 208, 1286–1288.CrossRefGoogle Scholar
  8. 8.
    Cheng Q, Lawrence G, Reed C, et al. (1997) Measurement of Plasmodium falciparum growth rate in vivo: a test of malaria vaccines. Am. J. Trop. Med. Hyg. 57, 495–500.Google Scholar
  9. 9.
    Murphy, S.C. and Breman, J.G. (2001) Gaps in the childhood malaria burden in Africa: cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia, and complications of pregnancy. Am. J. Trop. Med. Hyg. 64(1–2 Suppl), 57–67.Google Scholar
  10. 10.
    Warrell, D.A., Molyneux, M.E., and Beales, P.F. (1990) Severe and complicated malaria. Trans. R. Soc. Trop. Med. Hyg. 84(Suppl 2), 1–65.Google Scholar
  11. 11.
    Holding, P.A. and Snow, R.W. (2001) Impact of Plasmodium falciparum malaria on performance and learning: review of the evidence. Am. J. Trop. Med. Hyg. 64(1–2 Suppl), 68–75.Google Scholar
  12. 12.
    Newton, C.R.J.N., Taylor, T.E., and Whitten, R.O. (1998) Pathophisiology of fatal falciparum malaria in African children Am. J. Trop. Med. Hyg. 58, 673–683.Google Scholar
  13. 13.
    Menendez, C., Fleming, A.F., and Alonso, P.L. (2000) Malaria-related anaemia. Parasitol. Today 16, 469–476.CrossRefGoogle Scholar
  14. 14.
    Day, K.P. and Marsh, K. (1991) Naturally acquired-immunity to Plasmodium falciparum. Immunoparasitol. Today 12, A68-A71.CrossRefGoogle Scholar
  15. 15.
    Baird, J.K. (1995) Host age as a determinant of naturally acquired immunity to Plasmodium falciparum. Parasitol. Today 11, 105–111.CrossRefGoogle Scholar
  16. 16.
    Alonso, P.L., Lindsay, S.W., Armstrong, J.R., et al. (1991) The effect of insecticide-treated bed nets on mortality of Gambian children. Lancet 337, 1499–1502.CrossRefGoogle Scholar
  17. 17.
    Snow, R.W., Omumbo, J.A., Lowe, B., et al. (1997) Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 349, 1650–1654.CrossRefGoogle Scholar
  18. 18.
    Gupta, S., Hill, A.V.S., Kwiatkowski, D., Greenwood, A.M., Greenwood, B.M., and Day, K.P. (1994) Parasite virulence and disease patterns in Plasmodium falciparum malaria. Proc. Nat. Acad. Sci. USA 91, 3715–3719.CrossRefGoogle Scholar
  19. 19.
    Marsh, K. (1992) Malaria-a neglected disease? Parasitol. 104(Suppl), S53-S69.CrossRefGoogle Scholar
  20. 20.
    Kassim, O.O., Ako-Anai, K.A., Torimiro, S.E., Hollowell, G.P., Okoye, V.C., and Martin, S.K. (2000) Inhibitory factors in breastmilk, maternal and infant sera against in vitro growth of Plasmodium falciparum malaria parasite. J. Trop. Pediatr. 46, 92–96.CrossRefGoogle Scholar
  21. 21.
    Clark, I.A., Rockett, K.A., and Cowden, W.B. (1991) Proposed link between cytokines, nitric oxide and human cerebral malaria. Parasitol. Today 7, 205–207.CrossRefGoogle Scholar
  22. 22.
    Perlmann, H., Helmby, H., Hagstedt, M., et al. (1994) IgE elevation and IgE antimalarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. Clin. Exp. Immunol. 97, 284–292.CrossRefGoogle Scholar
  23. 23.
    Kurtzhals, J.A.L., Adabayeri, V., Goka, B.Q., et al. (1998) Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria. Lancet 351, 1768–1772.CrossRefGoogle Scholar
  24. 24.
    Kwiatkowski, D. (1990) Tumor necrosis factor, fever and fatality in falciparum malaria. Immunol. Letters 25, 213–216.CrossRefGoogle Scholar
  25. 25.
    Cohen, S., McGregor, I.A., and Carrington, S. (1961) Gamma globulin and acquired immunity to human malaria. Nature 192, 733–737.CrossRefGoogle Scholar
  26. 26.
    McGregor, I.A. and Carrington, S. (1963) Treatment of East African P. falciparum malaria with West African human gammaglobulin. Trans. R. Soc. Trop. Med. Hyg. 57, 170–175.CrossRefGoogle Scholar
  27. 27.
    Sabchareon, A., Burnouf, T., Ouattara, D., et al. (1991) Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. Am. J. Trop. Med. Hyg. 45, 297–308.Google Scholar
  28. 28.
    Bouharoun-Tayoun, H., Oeuvray C., Lunel F., and Druilhe P. (1995) Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J. Exp. Med. 182, 409–418.CrossRefGoogle Scholar
  29. 29.
    Bouharoun-Tayoun, H. and Druilhe, P. (1992) Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity. Infect. Immun. 60, 1473–1481.Google Scholar
  30. 30.
    Marsh, K., Otoo, L., Hayes, R.J., Carson, D.C., and Greenwood, B.M. (1989) Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection. Trans. R. Soc. Trop. Med. Hyg. 83, 293–303.CrossRefGoogle Scholar
  31. 31.
    Moore, S.A., Surgey, E.G., and Cadwgan, A.M. (2002) Malaria vaccines: where are we and where are we going? Lancet Infect. Dis. 2, 737–743.CrossRefGoogle Scholar
  32. 32.
    Taylor-Robinson, A.W., and Smith, E.C. (1999) A role for cytokines in potentiation of malaria vaccines through immunological modulation of blood stage infection. Immunol. Rev. 171, 105–123.CrossRefGoogle Scholar
  33. 33.
    Good, M.F., Quakyi, I.A., Saul, A., Berzofsky, J.A., Carter, R., and Miller, L.H. Human T clones reactive to the sexual stages of Plasmodium falciparum malaria. High frequency of gamete-reactive T cells in peripheral blood from nonexposed donors. J. Immunol. 138, 306–311.Google Scholar
  34. 34.
    Balde, A.T., Arbot, G., Tall, A., Spiegel, A., and Roussilhon, C. (2000) Apoptosis modulation in mononuclear cells recovered from individuals exposed to Plasmodium falciparum infection. Parasite Immunol. 22, 307–318.CrossRefGoogle Scholar
  35. 35.
    Hviid, L., Kurtzhals, J.A., Goka, B.Q., et al. (1997) Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria. Infect. Immun. 65, 4090–4093.Google Scholar
  36. 36.
    Jakobsen, PH., Hviid, L., Theander, T.G., et al. (1993) Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum. Infect. Immun. 6, 268–273.Google Scholar
  37. 37.
    Menendez, C. (1995) Malaria during pregnancy: a priority area of malaria research and control. Parasitol. Today 11, 178–183.CrossRefGoogle Scholar
  38. 38.
    MacGregor, I.A. (1987) Thoughts on malaria in pregnancy with consideration of some factors which influence remedial strategies. Parassitologia 29(2–3), 153–163.Google Scholar
  39. 39.
    Verhoeff, F.H., Brabin, B.J., Hart, C.A., Chimsuku, L., Kazembe, P., and Broadhead, R.L. (1999) Increased prevalence of malaria in HIV infected pregnant women and its implications for malaria control. Trop. Med. Hlth. 4, 5–12.CrossRefGoogle Scholar
  40. 40.
    Wickramasuriya GAW. (1937) Malaria and Ankylostomiasis in the Pregnant Woman. Their more serious complications and sequelae. Oxford University Press, UK, pp. 52,57.Google Scholar
  41. 41.
    Menendez, C., Ordi, J., Ismail, M.R., et al. (2000) The impact of placental malaria on gestational age and birth weight. J. Infect. Dis. 181, 1740–1745.CrossRefGoogle Scholar
  42. 42.
    Giglioli, G. (1972) Changes in the pattern of mortality following the eradication of hyperendemic malaria from a highly susceptible community. Bull. WHO 46, 181–202.Google Scholar
  43. 43.
    Ordi, J., Menendez, C., Ismail, MR., et al. (1998) Massive chronic intervillositis associated with malaria infection. Am. J. Surg. Pathol. 22, 1006–1010.CrossRefGoogle Scholar
  44. 44.
    Fried, M. and Duffy, P.E. (1996) Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta. Science 272, 1502–1504.CrossRefGoogle Scholar
  45. 45.
    Lindsay, S., Ansell, J., Selman, C., Cox, V., Hamilton, K., and Walraven, G. (2000) Effect of pregnancy on exposure to malaria mosquitoes. Lancet 55, 1972.CrossRefGoogle Scholar
  46. 46.
    World Health Organisation. (2000) The African Summit on Roll Back Malaria. WHO, Geneva.Google Scholar
  47. 47.
    Edington, G.M. (1954) Cerebral malaria in the Gold Coast African: four autopsy reports. Ann. Trop. Med. Parasitol. 48, 300–306.Google Scholar
  48. 48.
    Schellenberg, D., Menendez, C., Kahigwa, E., et al. (1999) African children with malaria in an area of intense Plasmodium falciparum transmission: features on admission to the hospital and risk factors for death. Am. J. Trop. Med. Hyg. 61, 431–438.Google Scholar
  49. 49.
    Bruce-Chwatt, L.J. (1952) Malaria in African infants and children in Southern Nigeria. Ann. Trop. Med. Parasitol. 79, 549–562.Google Scholar
  50. 50.
    Frood, J.D.L., Whitehead, R.G., and Coward, W.A. (1971) Relationship between pattern of infection and development of hypoalbuminaemia and hypo-betalipoproteinaemia in rural Ugandan children. Lancet ii, 1047–1049.CrossRefGoogle Scholar
  51. 51.
    Murray, M.J., Murray, A.B., Murray, M.B., and Murray, C.J. (1978) The adverse effect of iron repletion on the course of certain infections. Brit. Med. J. 2, 1113–1115.CrossRefGoogle Scholar
  52. 52.
    Gera, T. and Sachdev, H.P.S. (2002) Effect of iron supplementation on incidence of infectious illness in children: systematic review. Brit. Med. J. 325, 1142–1152.CrossRefGoogle Scholar
  53. 53.
    Hautvast, J.L., Tolboom, J.J., West, C.E., Kafwembe, E.M., Sauerwein, R.W., and van Staveren, W.A. (1998) Malaria is associated with reduced serum retinol levels in rural Zambian children. Int. J. Vitam. Nutr. Res. 68, 384–388.Google Scholar
  54. 54.
    Filteau, S.M., Morris, S.S., Abbott, RA., Tomkins, A.M., Kirkwood, B.R., Arthur, P., et al. (1993) Influence of morbidity on serum retinol of children in a community-based study in northern Ghana. Am. J. Clin. Nutr. 58, 192–197.Google Scholar
  55. 55.
    Shankar, A.H., Genton, B., Semba, R.D., et al. (1999) Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: a randomised trial. Lancet 354, 203–209.CrossRefGoogle Scholar
  56. 56.
    Binka, F.N., Ross, D.A., Morris, S.S., et al. (1995) Vitamin A supplementation and childhood malaria in northern Ghana. Am. J. Clin. Nutr. 61, 853–859.Google Scholar
  57. 57.
    Gibson, R.S. and Huddle, J.M. (1998) Suboptimal zinc status in pregnant Malawian women: its association with low intakes of poorly available zinc, frequent reproductive cycling, and malaria. Am. J. Clin. Nutr. 67, 702–709.Google Scholar
  58. 58.
    Shankar, A.H., Genton, B., Baisor, M., et al. (2000) The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea. Am. J. Trop. Med. Hyg. 62, 663–669.Google Scholar
  59. 59.
    Muller, O., Becher, H., van Zweeden, A.B., et al. (2001) Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo controlled trial. Brit. Med. J. 322, 1–6.CrossRefGoogle Scholar
  60. 60.
    Fleming, A.F. (1989) Tropical obstetrics and gynaecology. 1. Anaemia in pregnancy in tropical Africa. Trans.R.Soc. Trop. Med. Hyg. 83, 441–448.CrossRefGoogle Scholar
  61. 61.
    Fleming, A.F., Ghatoura, G.B., Harrison, K.A., Briggs, N.D., Dunn, D.T. (1986) The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria. Ann. Trop. Med. Parasitol. 80, 211–233.Google Scholar
  62. 62.
    van Hensbroek, M.B., Morris-Jones, S., Meisner, S., et al. (1995) Iron, but not folic acid, combined with effective antimalarial therapy promotes haematological recovery in African children after acute falciparum malaria. Trans.R.Soc. Trop. Med. Hyg. 89, 672–676.CrossRefGoogle Scholar
  63. 63.
    Bates, C.J., Powers, H.J., Lamb, W.H., Anderson, B.B., Perry, G.M., and Vullo, C. (1986) Antimalarial effects of riboflavin deficiency. Lancet 1, 329–330.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Clara Menéndez
  • Carlota Dobaňo

There are no affiliations available

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