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Chemoprevention Strategies for Esophageal Squamous Cell Carcinoma

  • Chapter
Cancer Chemoprevention

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Esophageal cancer is the eighth most common form of malignant disease in the world, and squamous cell carcinoma is the predominant histologic subtype (1–3). Esophageal squamous cell carcinoma (ESC) typically remains asymptomatic until the tumor reaches an advanced stage. Thus, patients often present with incurable disease, which is reflected by the ESC 5-yr survival rate of approximately 10%. Early detection programs have been implemented in select high-risk populations. However, such initiatives have been only modestly successful, primarily because an effective, affordable, and acceptable screening technique is not currently available. Existing data from a variety of sources suggest that chemoprevention may represent a viable approach to ESC prevention. In this chapter, current concepts regarding the key aspects of ESC chemoprevention are reviewed. Risk stratification and biomarker selection are discussed initially, followed by a more comprehensive overview of promising candidate agents for future ESC chemoprevention trials.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN

    Paul J. Limburg MD, MPH

  2. Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

    Philip R. Taylor MD, ScD & Sanford M. Dawsey MD

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  1. Paul J. Limburg MD, MPH
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  2. Philip R. Taylor MD, ScD
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  3. Sanford M. Dawsey MD
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Editors and Affiliations

  1. Biomedical Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD

    Gary J. Kelloff MD

  2. Gastrointestinal and Other Cancers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD

    Ernest T. Hawk MD, MPH

  3. CCS Associates, Mountain View, CA

    Caroline C. Sigman PhD

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Limburg, P.J., Taylor, P.R., Dawsey, S.M. (2005). Chemoprevention Strategies for Esophageal Squamous Cell Carcinoma. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59259-768-0_27

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