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Antiinflammatories and Chemoprevention

NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism

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Book cover Cancer Chemoprevention

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

As demonstrated in this and the following chapters of this volume, there has been a virtual explosion of interest in the prostanoids—their formation, metabolism and catabolism, physiologic roles, and pathophysiologic involvement in the related disease processes of inflammation and carcinogenesis. With the understanding that there are two major forms of cyclooxygenase (COX-1 and COX-2), an enzyme that is critical to prostanoid synthesis, and the development of pharmacologic and genetic tools to selectively inhibit each form and examine the consequences of their activity, it is possible to conduct meaningful animal experiments and human trials to establish or repudiate their clinical importance. This opportunity has opened many challenging and valuable discussions within and among the academic, regulatory, patient, and pharmaceutical communities.

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  1. Gary B. Gordon MD, PhD
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  2. Gary J. Kelloff MD
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  3. Caroline C. C. Sigman PhD
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Editors and Affiliations

  1. National Institutes of Health, Rockville, MD, USA

    Gary J. Kelloff MD  & Ernest T. Hawk MD, MPH  & 

  2. CCS Associates, Mountain View, CA, USA

    Caroline C. Sigman PhD

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Gordon, G.B., Kelloff, G.J., Sigman, C.C.C. (2004). Antiinflammatories and Chemoprevention. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-767-3_5

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  • DOI: https://doi.org/10.1007/978-1-59259-767-3_5

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