Chemoprevention by Isothiocyanates

  • Stephen S. Hecht
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Isothiocyanates are among the most effective known chemopreventive agents (1). Examples of complete inhibition of carcinogenicity in laboratory animals through relatively low doses of isothiocyanates are not unusual. Many isothiocyanates occur naturally as glucosinolate conjugates in frequently consumed cruciferous vegetables (2). Consistent with the animal carcinogenicity data, three recent epidemiologic studies have demonstrated that human consumption of isothiocyanates in vegetables decreases lung cancer risk (3–5). Other studies have shown that consumption of genus Brassica vegetables is protective against lung cancer (6). Collectively, these data indicate that isothiocyanates have substantial potential for chemoprevention of human cancers.


Chemopreventive Agent Cruciferous Vegetable Quinone Reductase Broccoli Sprout Lung Tumorigenesis 
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© Springer Science+Business Media New York 2004

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  • Stephen S. Hecht

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