Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs

  • Arthur G. Schwartz
  • Laura L. Pashko
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Dehydroepiandrosterone (DHEA) is a major adrenal cortical steroid in humans (1, 2). The plasma levels of DHEA and its sulfated ester rise early in life, reaching a maximum in the second decade, and decline thereafter throughout adult life, whereas cortisol levels rise linearly with age (3). DHEA and related steroids are potent, non-competitive inhibitors of mammalian glucose-6 phosphate dehydrogenase (G6PDH), the rate-limiting enzyme of the pentose phosphate pathway, which is a major source of fivecarbon sugars as well as nicotinamide adenine dinucleotide phosphate (NADPH), a critical modulator of cellular redox potential. NADPH supplies reducing equivalents for several reactions that generate oxygenfree radicals, which, in addition to their mutagenicity, act as intermediate messengers that stimulate mitogenesis and upregulate inflammation.


West Nile Virus Pentose Phosphate Pathway Nicotinamide Adenine Dinucleotide Phosphate Leydig Cell Tumor Reduce Weight Gain 
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© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Arthur G. Schwartz
  • Laura L. Pashko

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