Abstract
In the US, one in six men will develop prostate cancer during his lifetime (1), and prostate cancer accounts for nearly 3% of all deaths in men over age 55 (2). Since prostate cancer is primarily a malignancy of the aged, these numbers are likely to increase as the population ages. Primary treatment for prostate cancer typically involves radical prostatectomy, external beam radiation, or brachytherapy (seeding the prostate with radioisotope). All these therapies lead to about a 30% rate of recurrence (2a). Androgen ablation is most often used as second-line therapy, since prostate-derived cancers are, at least initially, androgen-dependent for growth. Androgen ablation is commonly achieved by surgical castration, the use of GnRH super-agonists to block LH release and thus inhibit testosterone synthesis, or the use of androgen antagonists alone or in combination with GnRH agonists.
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Chapman, M.S., Chang, W.Y., Negro-Vilar, A., Miner, J.N. (2004). Searching For SARA. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-767-3_14
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DOI: https://doi.org/10.1007/978-1-59259-767-3_14
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