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Inducers of Enzymes That Protect Against Carcinogens and Oxidants

Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane
  • Thomas W. Kensler
  • Paul Talalay
Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

The multiple stages of carcinogenesis offer many potential strategies for protection. However, in the majority of tests conducted in animal models, protection has been achieved by administering the chemopreventive agent prior to and/or concurrently with the exposure to the carcinogen. Considering this temporal relationship between the administration of anticarcinogen and carcinogen, it seems likely that these agents act at least in part to alter the metabolism and disposition of carcinogens, thereby altering events that are critical to the initial interactions of chemical carcinogens with biomolecules.

Keywords

Enzyme Inducer Chemopreventive Agent Aberrant Crypt Focus Cruciferous Vegetable Antioxidant Response Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Thomas W. Kensler
  • Paul Talalay

There are no affiliations available

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