Lead Toxicity in the Skeleton and Its Role in Osteoporosis

  • J. Edward Puzas
  • James Campbell
  • Regis J. O’Keefe
  • Randy N. Rosier
Part of the Nutrition and Health book series (NH)


This discussion focuses on the role that lead plays as a risk factor for osteoporosis and as an agent that may compromise skeletal development and fracture healing. The adverse effects of lead in our environment have been demonstrated in many systems. However, its effect on the skeleton have not been widely studied. With the advent of laws removing this toxic agent from our environment, the harmful effects on soft tissues will most certainly begin to decline. Nevertheless, with nearly 95% of the body burden of lead residing in bone and with a lead halflife in the skeleton measured in decades, the effects of this heavy metal on bone cell function could persist for an entire lifetime.


Bone Mineral Density Lead Exposure Blood Lead Level Lead Toxicity Lead Intoxication 
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© Springer Science+Business Media New York 2004

Authors and Affiliations

  • J. Edward Puzas
  • James Campbell
  • Regis J. O’Keefe
  • Randy N. Rosier

There are no affiliations available

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