Mechanotransduction Pathways in Cartilage

  • Qian Chen


It is known that cartilage homeostasis is regulated by mechanical signals during limb development, fracture repair, and skeletal remodeling. The dramatic effect of mechanical stimulation of bone growth is best illustrated by distraction osteogenesis, in which distraction forces are applied to a healing limb to stimulate bone formation (1,2). When distraction stress is applied at certain amplitude and frequency, new bone formation is sustained, thereby achieving limb lengthening. In recent years, great progress has been made in understanding how new bone formation is activated by mechanical stimulation and the cellular signal transduction pathway to receive and convert mechanical signals into tissue growth and regeneration. In this chapter, we will summarize recent studies elucidating the molecular mechanism of biophysical regulation of cartilage growth, an important step during endochondral bone formation and fracture healing.


Bone Morphogenetic Protein Fracture Healing Distraction Osteogenesis Chondrocyte Proliferation Matrix Deformation 
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© Springer Science+Business Media New York 2004

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  • Qian Chen

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