The Skeleton pp 249-261 | Cite as

Computer Simulations of Cancellous Bone Remodeling

  • Jacqueline C. van der Linden
  • Harrie Weinans
  • Jan A. N. Verhaar


The bone remodeling process is essential for the maintenance of our skeleton. It enables adaptation of the bone mass and architecture to changes in external loads (1,2), and it prevents accumulation of damage (3,4). Damage accumulation is prevented by a frequent turnover of the bone tissue by the bone remodeling process: old tissue is replaced by new tissue. Bone remodeling is performed by two types of cells: osteoclasts, which are multinucleated bone resorbing cells, and osteoblasts, which are bone-forming cells. Osteoclasts resorb packets of bone tissue, and osteoblasts replace the resorbed tissue with new mineralized bone tissue (see Fig. 1).


Bone Remodel Cancellous Bone Resorption Cavity Bone Remodel Process Connectivity Density 
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© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Jacqueline C. van der Linden
  • Harrie Weinans
  • Jan A. N. Verhaar

There are no affiliations available

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