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Mammary Epithelial Stem Cells

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Adult Stem Cells

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Abstract

Mammary gland development and function would not be possible without tissue-specific stem cells. The cycle of pregnancy-associated proliferation, differentiation, apoptosis, and remodeling, which may occur many times during the mammalian reproductive lifespan, can only be explained by the presence of a long-lived population of stem cells with a near-unlimited capacity to generate functional cells. The aim of this chapter, therefore, is to review the evidence for the presence of stem cells in the mammary gland, to describe the progress in isolating and characterizing these stem cells, to discuss the role of stem cells in mammary gland carcinogenesis, and to speculate whether mammary stem cells share properties with stem cells in other adult tissues.

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Authors
  1. Elizabeth Anderson
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  2. Robert B. Clarke
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Editors and Affiliations

  1. Hormones, Growth, and Development Program, Ottawa Health Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada

    Kursad Turksen

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Anderson, E., Clarke, R.B. (2004). Mammary Epithelial Stem Cells. In: Turksen, K. (eds) Adult Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-732-1_10

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  • DOI: https://doi.org/10.1007/978-1-59259-732-1_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-392-3

  • Online ISBN: 978-1-59259-732-1

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