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Linking Biochemical, Pathologic, and Clinical Events in Acute Coronary Syndromes

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Management of Acute Coronary Syndromes

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Acute coronary syndromes represent the ultimate clinical expression of biochemical events and pathological processes occurring within atherosclerotic plaques. The sudden or rapidly progressive transition from a stable to an unstable clinical state implies increasing activity within the atheromatous core. Indeed, patients with unstable angina, non-ST-segment elevation myocardial infarction (MI), and ST-segment elevation MI are all at the metamorphosis stage of their disease. Much like physiologic hemostasis, pathologic thrombosis, representing the final common event that links acute coronary syndromes, represents a response to localized vascular injury and inflammation; however, unlike normal hemostasis, the cascade of events that follows is poorly regulated and responsible for compromised myocardial perfusion and at times cellular death.

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  1. Richard C. Becker MD
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  1. Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Christopher P. Cannon MD

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Becker, R.C. (1999). Linking Biochemical, Pathologic, and Clinical Events in Acute Coronary Syndromes. In: Cannon, C.P. (eds) Management of Acute Coronary Syndromes. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-731-4_2

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  • DOI: https://doi.org/10.1007/978-1-59259-731-4_2

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