Abstract
Molecular analysis of chromosomal translocations in human lymphoma cells has led to the identification of new cellular protooncogenes that contribute to lymphoma formation. Genes encoding for the B-cell immunoglobulin heavy chain (IgH) and T-cell antigen receptors (TCR) are frequent targets for such rearrangements. Many of these rearrangements are detectable by Southern blot analysis, hybridizing with the immunoglobulin (Ig), TCR, or appropriate DNA probes for other genes involved at the point of translocation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Selected References
Cotter F. Molecular pathology of lymphomas. Cancer Surveys 1993; 16: 157–174.
Cotter F, Johnson P, Hall P, et al. Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene 1994; 9: 3049–3055.
de Boer CJ, van Krieken JH, Schuuring E, Kluin PM. Bcl-1/cyclin D1 in malignant lymphoma. Ann Oncol 1997; 8 Suppl 2: 109–117.
Korsmeyer SJ. Bc1–2: an antidote to programmed cell death. Cancer Surveys 1992; 15: 105–118.
Mason DY, Gatter KC. Annotation. Not another lymphoma classification! Br J Haematol 1992; 90: 493–497.
Monni 0, Joensuu H, Franssila K, Klefstrom J, Alitalo K, Knuutila S. BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood 1997; 90: 1168–1174.
Rabbitts TH. Translocations, master genes and differences between the origins of acute and chronic leukemia. Cell 1991; 67: 641–644.
Rabbitts TH. Chromosomal translocations in human cancer. Nature 1994; 372: 143–149.
Tycko B, Sklar J. Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model. Cancer Cells 1990; 2: 1–8.
Ye BH, Chaganti S, Chang CC, et al. Chromosomal translocations cause deregulated BCL6 expression by promotor substitution in B cell lymphoma. EMBO J 1995; 14: 6209–6217.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Cotter, F.E. (1998). Lymphomas. In: Jameson, J.L. (eds) Principles of Molecular Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-726-0_27
Download citation
DOI: https://doi.org/10.1007/978-1-59259-726-0_27
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4757-6272-3
Online ISBN: 978-1-59259-726-0
eBook Packages: Springer Book Archive