Abstract
Recombinant DNA technology has provided invaluable tools for understanding the molecular basis of cardiovascular diseases. Elucidation of the underlying molecular genetic mechanisms of cardiovascular disease has led to the emergence of gene therapy as an appealing therapeutic approach. Gene therapy involves the introduction and expression of recombinant DNA in order to ameliorate or cure a disease condition. Despite the extensive publicity devoted to gene therapy, it must be emphasized that this field is still very much in its infancy, and fundamental questions regarding efficacy, safety, and clinical benefit remain unanswered. Initial clinical trials in cardiovascular gene therapy are at an early stage, and the place of gene therapy within the armamentarium of cardiovascular therapeutics remains uncertain. This chapter is devoted principally to a review of the theoretical basis for cardiovascular gene therapy, as established by in vitro and preclinical animal experiments. In addition, the two currently approved human cardiovascular gene-therapy trials (familial hypercholesterolemia [FH; MIM # 14389] and peripheral arterial disease) are discussed, and the likely future directions of the field are summarized.
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Vassalli, G., Dichek, D.A. (1998). Cardiovascular Gene Therapy. In: Jameson, J.L. (eds) Principles of Molecular Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-726-0_18
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DOI: https://doi.org/10.1007/978-1-59259-726-0_18
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4757-6272-3
Online ISBN: 978-1-59259-726-0
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