Abstract
Full understanding of the mechanisms of sulfur mustard (HD) toxicity has not yet been attained. Part of the problem rests with the high degree of reactivity of this alkylating agent and its multiple cellular targets. Disturbance of these targets, either directly by alkylation or as secondary results of disruptions to biochemical pathways, gives rise to a confusing array of cellular and tissue responses to HD. Recent data suggest that alteration of gene expression (1) and modification of cellular differentiation (2) are two pathways that could contribute to the toxic manifestations of HD exposure.
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© 1999 Springer Science+Business Media New York
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Smith, W.J. (1999). Altered Expression of Intracellular and Surface Antigens by Cultured Human Epidermal Keratinocytes Exposed to Sulfur Mustard. In: Salem, H., Katz, S.A. (eds) Toxicity Assessment Alternatives. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-718-5_17
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DOI: https://doi.org/10.1007/978-1-59259-718-5_17
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4757-6863-3
Online ISBN: 978-1-59259-718-5
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