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Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms

  • Chapter
Insulin Resistance

Part of the book series: Contemporary Endocrinology ((COE,volume 12))

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Abstract

The degree of sensitivity of skeletal muscle to insulin is widely variable in humans. Diseases such as non-insulin-dependent diabetes mellitus (NIDDM or Type 2 diabetes) have a characteristic component of muscle insulin resistance. Many obese, nondiabetic individuals are also insulin resistant. However, healthy people who are not overweight also display a spectrum of insulin sensitivity. For example, when the euglycemic, hyperinsulinemic clamp technique is used to measure insulin-stimulated glucose uptake in such healthy individuals, there is a two-to threefold range in glucose uptake. Therefore, some percentage of even lean, healthy people can be said to be insulin resistant. Presumably, the ability of the pancreas to secrete sufficient insulin prevents this insulin resistance from developing into abnormal glucose tolerance.

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Authors
  1. Lawrence J. Mandarino PhD
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  1. Shaman Pharmaceuticals, Inc., South San Francisco, CA, USA

    Gerald M. Reaven MD

  2. Stanford University School of Medicine, Stanford, CA, USA

    Gerald M. Reaven MD

  3. Stanford University School of Medicine, Stanford, CA, USA

    Ami Laws MD

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Mandarino, L.J. (1999). Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms . In: Reaven, G.M., Laws, A. (eds) Insulin Resistance. Contemporary Endocrinology, vol 12. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-716-1_10

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  • DOI: https://doi.org/10.1007/978-1-59259-716-1_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-086-1

  • Online ISBN: 978-1-59259-716-1

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