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The IGF System pp 111–139Cite as

Molecular Biology of the IGF Binding Proteins

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Part of the book series: Contemporary Endocrinology ((COE,volume 17))

Abstract

In adult animals, 80–85% of insulin-like growth factor-I and -II (IGFs) circulate as 150-kDa ternary complexes. These ternary complexes are comprised of one molecule each of IGF, IGF binding protein-3 (IGFBP-3), the predominant IGFBP in serum, and an acid-labile subunit (ALS) (1). Serum also contains lower molecular weight complexes that are not fully saturated with IGFs. These complexes are comprised of the other smaller binding proteins (IGFBP-1, -2, -4, -5, and -6). These six IGFBPs are structurally related to each other (Fig. 1) and bind IGF-I and IGF-II with high affinity (2,3), but share no homology with the IGF receptors. These proteins, however, have different biochemical and biological characteristics that are due to differences in their primary structure. The present chapter summarizes current molecular information on the six IGFBPs and ALS (regulation of gene expression, cDNA, and gene organization). This summary, however, does not attempt to be encyclopedic, but rather to provide a general outline on the molecular aspects of the six high-affinity IGF-binding proteins, underlying their similarities and differences.

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Authors
  1. Guck T. Ooi PhD
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  2. Yves R. Boisclair PhD
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Editors and Affiliations

  1. Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, OR, USA

    Ron G. Rosenfeld MD

  2. Oregon Health Sciences University, Portland, OR, USA

    Charles T. Roberts Jr. PhD

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Ooi, G.T., Boisclair, Y.R. (1999). Molecular Biology of the IGF Binding Proteins. In: Rosenfeld, R.G., Roberts, C.T. (eds) The IGF System. Contemporary Endocrinology, vol 17. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-712-3_6

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  • DOI: https://doi.org/10.1007/978-1-59259-712-3_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-138-7

  • Online ISBN: 978-1-59259-712-3

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