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IGFs and Skeletal Muscle

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Book cover The IGF System

Part of the book series: Contemporary Endocrinology ((COE,volume 17))

Abstract

The insulin-like growth factors (IGFs) are unique in that they are the only known mitogens that, when free of other serum components, stimulate both the proliferation and differentiation of skeletal muscle cells. This dual effect of IGFs is of particular interest because these two processes are believed to be mutually exclusive in this tissue and in a wide variety of cell types (1). Thus, exploring this model of IGF action in skeletal muscle provides an opportunity to address a fundamental issue in cell biology: understanding the mechanisms that influence the decision of a particular cell type to proliferate or differentiate. The focus of this chapter is on the interface of IGF biology with that of skeletal muscle embryogenesis/differentiation and cell cycle regulation, with particular emphasis on exploring the mechanisms by which IGFs influence the decision of skeletal muscle cells to proliferate or differentiate.

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Authors
  1. Stephen M. Rosenthal MD
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Editors and Affiliations

  1. Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, OR, USA

    Ron G. Rosenfeld MD

  2. Oregon Health Sciences University, Portland, OR, USA

    Charles T. Roberts Jr. PhD

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Rosenthal, S.M. (1999). IGFs and Skeletal Muscle. In: Rosenfeld, R.G., Roberts, C.T. (eds) The IGF System. Contemporary Endocrinology, vol 17. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-712-3_21

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  • DOI: https://doi.org/10.1007/978-1-59259-712-3_21

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-138-7

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