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Posttranslational Modification of the IGF Binding Proteins

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Book cover The IGF System

Part of the book series: Contemporary Endocrinology ((COE,volume 17))

Abstract

Primary sequences for the six currently characterized insulin-like growth factor binding proteins (IGFBPs) range in length from 201 amino acids for rat IGFBP-6 to 289 amino acids for human IGFBP-2 (1). Sequence analyses indicate extensive homology among the IGFBPs in the amino(N)- and carboxy(C)-terminal domains with their conserved cysteines, domains that confer the ability to bind IGF ligand with high affinity. The homology within the IGF-binding end portions of the molecule defines the family of IGFBPs. However, it is the unique central domain that makes each IGFBP structurally and ultimately functionally distinctive.

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  1. Cheryl A. Conover PhD
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Editors and Affiliations

  1. Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, OR, USA

    Ron G. Rosenfeld MD

  2. Oregon Health Sciences University, Portland, OR, USA

    Charles T. Roberts Jr. PhD

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Conover, C.A. (1999). Posttranslational Modification of the IGF Binding Proteins. In: Rosenfeld, R.G., Roberts, C.T. (eds) The IGF System. Contemporary Endocrinology, vol 17. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-712-3_16

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  • DOI: https://doi.org/10.1007/978-1-59259-712-3_16

  • Publisher Name: Humana Press, Totowa, NJ

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