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Reproduction in Rhesus Monkeys Chronically Exposed to Δ9-Tetrahydrocannabinol

  • E. N. Sassenrath
  • L. F. Chapman
  • G. P. Goo

Abstract

Data is reported from 46 matings between 11 undrugged adult rhesus monkey breeders and eight comparable breeders that had received daily oral doses of Δ9-THC at 2.4 mg per kg for a 5-yr period. Matings of drugged breeders showed no decrease in conceptions, but a 42% reproductive loss for matings of THC-treated females compared to an 8–11% loss for matings of undrugged females. The observed losses were not related to parity of mother or duration of drug intake and were nonspecific relative to stage of pregnancy; i.e., they occurred as resorptions, abortions, fetal deaths, stillbirths, and neonatal deaths. Nonviable term offspring appeared grossly normal, but exhibited a variety of nonspecific abnormalities on histopathological evaluation.

Viable offspring of drugged mothers also appeared grossly normal. However, male infants had significantly lower birth rates. In general, offspring of THC-treated mothers tended to show subtle behavioral differences from control offspring in both responsivity to environmental stimuli and adaptability in peer social environments.

The nonspecific and variable nature of these effects in a controlled primate test system suggests that such effects would be difficult to document in relation to marihuana use in the human population.

Keywords

Inguinal Hernia Breeding Season Rhesus Monkey Fetal Alcohol Syndrome Control Mother 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Borgen, L. A., Davis, W. M. and Pace, H. B. (1973) Effects of prenatal delta-nine-tetrahydrocannabinol on the development of rat offspring. Pharmacol. Biochem. Behan 1, 203.CrossRefGoogle Scholar
  2. 2.
    Bourne, G. H. (1975) Collected anatomical and physiological data from the rhesus monkey in The Rhesus Monkey, vol. 1, ( Bourne, G. H., ed.). Academic, New York.Google Scholar
  3. 3.
    Braude, M. C. (1976) Genetics and reproduction, introduction in Pharmacology of Marihuana, vol. 2, ( Braude M. C. and Szara, S., eds) Raven, New York.Google Scholar
  4. 4.
    Carakushansky, G., Neu, R. L. and Gardner, L. I. (1969) Lysergide and cannabis as possible teratogens in man. Lancet 1, 150.PubMedCrossRefGoogle Scholar
  5. 5.
    Clarren, S. K. and Smith, D. W. (1978) The fetal alcohol syndrome. New Eng. J. Med. 298, 1063.Google Scholar
  6. 6.
    Finney, D. J., Latscha, R., Bennett, B. M. and Hsu, P. (1963) Tables for testing Significance in a 2 x2 Contingency Table. University Press, Cambridge.Google Scholar
  7. 7.
    Fleischman, R. W., Hayden, D. W., Rosenkrantz, H. and Braude, M. C. (1975) Teratologic evaluation of 49tetrahydrocannabinol in mice, including a review of the literature. Teratology. 12, 47.PubMedCrossRefGoogle Scholar
  8. 8.
    Fournier, E., Rosenberg, E., Hardy, N. and Nahas, G. (1976) Teratologic effects of cannabis extracts in rabbits: a preliminary study in Marihuana: Chemistry, Biochemistry, and Cellular Effects (Nahas, G. G., ed.) Springer-Verlag, New York, pp. 457–468.Google Scholar
  9. 9.
    Geber, W. F. and Schramm, L. C. (1969) Effects of marihuana extract on fetal hamsters and rabbits. Toxic. Appl. Pharmacol. 14, 276.PubMedCrossRefGoogle Scholar
  10. 10.
    Geber, W. F. and Schramm, L. C. (1969) Teratogenicity of marihuana extract as influenced by plant origin and seasonal variation. Arch. Int. Pharmacol. Ther. 177, 224.Google Scholar
  11. 11.
    Grilly, D. M., Ferraro, D. P. and Braude, M. C. (1974) Observations on the reproductive activity of chimpanzees following long-term exposure to marihuana. Pharmacology 11, 304.PubMedCrossRefGoogle Scholar
  12. 12.
    Haley, S. L., Wright, P. L., Plank, J. B., Keplinger, M. L., Braude, M. C. and Calandra, J. C. (1972) The effect of natural and synthetic delta-9-tetrahydrocannabinol on fetal development. Toxicol. Appl. Pharmacol. 25, 450.Google Scholar
  13. 13.
    Harbison, R. D. and Mantilla-Plata, B. (1972) Prenatal toxicity, maternal distribution and placental transfer of tetrahydrocannabinol. J. Pharmacol. Exp. Ther. 180, 446.PubMedGoogle Scholar
  14. 14.
    Harbison, R. D., Mantilla-Plata, B. and Lubin, D. J. (1977) Alternation of 9-tetrahydrocannabinol-induced tetratogenicity by stimulation and inhibition of its metabolism. Jour. Pharm. Exp. Ther. 202, 455.Google Scholar
  15. 15.
    Hecht, F., Beals, R. K., Lees, M. H., Jolly, H. and Roberts, P. (1968) Lysergic acid diethylamide and cannabis as possible teratogens in man Lancet 2, 1087.PubMedCrossRefGoogle Scholar
  16. 16.
    Joneja, M. G. (1977) Effects of A9-tetrahydrocannabinol on hamster fetuses. J. Tox. Envir. Health. 2, 1031.CrossRefGoogle Scholar
  17. 17.
    Pace, H. B., Davis, W. M. and Borgen, L. A. (1971) Teratogenesis; and marijuana. Ann. N. Y. Acad. Sci. 191, 123.CrossRefGoogle Scholar
  18. 18.
    Persaud, T. V. N. and Ellington, A. C. (1967) Cannabis in early pregnancy. Lancet 2, 1306.Google Scholar
  19. 19.
    Persaud, T. V. N. and Ellington, A. C. (1968) Teratogenic activity of canabis resin. Lancet 2, 406PubMedCrossRefGoogle Scholar
  20. 20.
    Phillips, R. N., Turk, R. F. and Forney, R. B. (1971) Acute toxicity of delta-nine tetrahydrocannabinol in rats and mice. Proc. Scott. Exp. Biol. Med. 136, 260.Google Scholar
  21. 21.
    Rosenkrantz, H., Fleishman, R. W. and Baker, J. R. (1978) Embryotoxicity of marihuana by inhalation. Fed. Proc. 37 (3), 737 (Abstract).Google Scholar
  22. 22.
    Sackett, G., Holm, R. and Landesman-Dwyer, S. (1975) Vulnerability for abnormal development: pregnancy outcomes and sex differences in macaque monkeys in Aberrant Development in Infancy: Human and Animal Studies ( Ellis N. R., ed.) Wiley New York.Google Scholar
  23. 23.
    Sassenrath, E. N. and Chapman, L. F. (1975) Tetrahydrocannabinol-induced manifestations of the `marihuana syndrome’ in group-living macaques. Fed. Proc. 34, 1666 (1975).Google Scholar
  24. 24.
    Sassenrath, E. N. and Chapman, L. F. (1976) primate social behavior as a method of analysis of drug action: studies with THC in monkeys. Fed. Proc. 35, 2238Google Scholar
  25. 25.
    Sassenrath, E. N., Goo, G. P. and Chapman, L. F. Behavioral effects of acute and long-term chronic exposure to 49-THC in group-living rhesus monkeys. pp. 693–712).Google Scholar
  26. 26.
    Uyeno, E. T. (1973) Delta-nine tetrahydrocannabinol administration during pregnancy of the rat. Proc. West. Pharmacol. Soc. 16, 64.Google Scholar
  27. 27.
    Wursch, M. S., Otis, L., Green, D. E. and Forrest, I. S. (1972) 3H-9-tetrahydrocannabinol metabolism in rhesus and squirrel monkeys. Proc. West. Pharmacol. Soc. 15, 68.Google Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • E. N. Sassenrath
  • L. F. Chapman
  • G. P. Goo

There are no affiliations available

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