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Cardiovascular Effects of Marihuana and Cannabinoids

  • Renaud Trouve
  • Gabriel Nahas

Abstract

In the isolated heart THC produces a biphasic effect on heart rate with an initial increase followed by a decrease. THC also decreases coronary flow and cardiac contractile force. The depressant effect of THC on cardiac contraction and coronary flow is antagonized by CBD and by Ca2+ antagonists. In humans, THC and marihuana induce increases in heart rate and blood pressure. In the supine position, postural hypotension is observed because of the peripheral vasodilation produced by the drug. THC produces a deregulation of the baroreflex. In dogs, cats, and rats, THC produces hypotension and bradycardia, indicating a predominance of the interaction of the parasympathetic outflow by THC in these animals. Marihuana smoking increases coronary insufficiency in patients with ischemic cardiac disease. Self-administration of cocaine before exercise will result in an increase in the tachycardia and a decreased efficiency. Marihuana smoking and THC have no therapeutic cardiac properties and are contraindicated in patients with coronary problems.

Keywords

Cardiovascular Effect Coronary Flow Marijuana Smoking Coronary Problem Parasympathetic Outflow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Renaud Trouve
  • Gabriel Nahas

There are no affiliations available

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