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Cannabinoids and the Cholinergic System

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Abstract

Δ9-Tetrahydrocannabinol (THC) decreases EEG activation and causes slow waves in the cat. The EEG slow-wave activity is accompanied by a concomitant decrease in acetylcholine release from the neocortex. The findings suggest that THC depresses the brainstem-activating system. Large doses of Δ8- and Δ- 9THC increase brain acetylcholine levels in rodents such as the mouse and rat, but this effect is not seen with minimal doses of the cannabinoids that show behavioral effects. The most dramatic change produced by THC is that brain acetylcholine utilization is reduced, primarily in the hippocampus.

Keywords

  • Cholinergic System
  • Acetylcholine Release
  • Marijuana Smoking
  • Brain Acetylcholine
  • Baseline Release

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1999 Springer Science+Business Media New York

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Domino, E.E. (1999). Cannabinoids and the Cholinergic System. In: Nahas, G.G., Sutin, K.M., Harvey, D., Agurell, S., Pace, N., Cancro, R. (eds) Marihuana and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-710-9_22

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  • DOI: https://doi.org/10.1007/978-1-59259-710-9_22

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5717-0

  • Online ISBN: 978-1-59259-710-9

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