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Animal Models for Insulin-Dependent Diabetes Mellitus

  • Chapter
Autoimmune Endocrinopathies

Part of the book series: Contemporary Endocrinology ((COE,volume 15))

Abstract

Insulin-dependent diabetes mellitus (IDDM) in humans is a complex disease. Environmental and genetic factors contribute in variable proportions to the etiopathogenesis. In order to develop effective strategies to predict, prevent, and treat diabetes, it is important to identify and characterize the individual factors involved in the disease process and to study synergistic effects that may control progression toward the clinical onset of diabetes. In human diabetes, this goal has proven cumbersome and complicated to pursue, owing to the lack of knowledge of the development of human autoimmune diseases, lack of human pancreatic islet tissue to study the target organ, as well as complex inheritance patterns (see also Chapter 12). Thus, the use of animals to study IDDM has contributed fundamentally to the current knowledge and to hypotheses aimed at clarifying the nature of the disease. The reader is referred to recent excellent reviews on animals with IDDM, including the nonobese diabetic (NOD) mouse (1–3) and the BioBreeding (BB) rat (4,5). This chapter will describe important animal models for IDDM and some of the implications of the research data that have been obtained by studying diabetes in these animals.

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Authors
  1. Sabine Bieg PhD
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  2. Åke Lernmark MD
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Editors and Affiliations

  1. Division of Endocrinology, Department of Medicine, The Wellesley Hospital, University of Toronto, Toronto, Ontario, Canada

    Robert Volpé MD, FRCP(C), FACP, FRCP

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Bieg, S., Lernmark, Å. (1999). Animal Models for Insulin-Dependent Diabetes Mellitus. In: Volpé, R. (eds) Autoimmune Endocrinopathies. Contemporary Endocrinology, vol 15. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-704-8_5

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  • DOI: https://doi.org/10.1007/978-1-59259-704-8_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4572-6

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