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Lupus pp 361–370Cite as

Balance Between Type 1 and Type 2 Cytokine-Secreting Cells

Impact on Disease Activity in Systemic Lupus Erythematosus

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Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

The overproduction of pathogenic autoantibodies is a key feature of systemic lupus erythematosus (SLE). Yet numerous studies indicate that autoantibodysecreting B cells in lupus patients are not abnormal. Rather, they appear to be stimulated by factors in the immune environment that trigger the production of autoantibodies. Immunostimulatory cytokines may cause this shift from a state of tolerance to autoimmunity.

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Authors
  1. Daniela Verthelyi
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  2. Dennis M. Klinman
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Editor information

Editors and Affiliations

  1. Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Gary M. Kammer MD

  2. Division of Rheumatology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

  3. Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, USA

    George C. Tsokos MD

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© 1999 Springer Science+Business Media New York

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Verthelyi, D., Klinman, D.M. (1999). Balance Between Type 1 and Type 2 Cytokine-Secreting Cells. In: Kammer, G.M., Tsokos, G.C. (eds) Lupus. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-703-1_22

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  • DOI: https://doi.org/10.1007/978-1-59259-703-1_22

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5686-9

  • Online ISBN: 978-1-59259-703-1

  • eBook Packages: Springer Book Archive

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