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Mechanisms of the Pathogenic Autoimmune Response in Lupus

From Mouse Models to Human Disease

  • Chapter
Lupus

Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

The pathogenesis of spontaneous systemic lupus erythematosus (SLE) appears to be the outcome of numerous abnormalities of the immune system, including a generalized hyperactivity of T and B cells (1–4). However, autoimmunity in lupus is not global; it is directed mainly against nuclear antigens (5–7). Although autoantibodies that bind DNA play a major role in the development of lupus nephritis, B cells of normal subjects can produce “natural” anti-DNA autoantibodies (8). Furthermore, DNA is only a target antigen and not the primary immunogen, because deliberate immunization with DNA does not lead to SLE (9,10). This chapter describes our studies on the NZB × SWR model, as well as human SLE that have simplified some of these complexities and paradoxes of lupus and are helping to define the primary immunogen(s) that drives the pathogenic autoimmune response in this disease (11).

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  1. Syamal K. Datta
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Editors and Affiliations

  1. Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Gary M. Kammer MD

  2. Division of Rheumatology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

  3. Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, USA

    George C. Tsokos MD

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Datta, S.K. (1999). Mechanisms of the Pathogenic Autoimmune Response in Lupus. In: Kammer, G.M., Tsokos, G.C. (eds) Lupus. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-703-1_12

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