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Pseudohypoparathyroidism

  • Chapter
Hormone Resistance Syndromes

Part of the book series: Contemporary Endocrinology ((COE,volume 14))

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Abstract

In 1942, Fuller Albright and his associates described three patients who presented with tetany and seizures, and were found to have hypocalcemia (1). These clinical and bio-chemical features were consistent with the diagnosis of hypoparathyroidism. However, unlike patients with parathyroid hormone (PTH) deficiency, these patients failed to show a rise in serum calcium or urinary phosphate in response to injected parathyroid extract (1). Albright speculated that this condition was owing to target organ (bone and kidney) resistance to PTH action, and dubbed this syndrome pseudohypoparathyroidism (PHP). This was the first description of hormone resistance in humans.

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Authors
  1. Ali Al-Zahrani MD
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  2. Michael A. Levine MD
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  3. William F. Schwindinger MD, PhD
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  1. Northwestern University Medical School, Chicago, IL, USA

    J. Larry Jameson MD, PhD

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© 1999 Springer Science+Business Media New York

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Al-Zahrani, A., Levine, M.A., Schwindinger, W.F. (1999). Pseudohypoparathyroidism. In: Jameson, J.L. (eds) Hormone Resistance Syndromes. Contemporary Endocrinology, vol 14. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-698-0_3

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  • DOI: https://doi.org/10.1007/978-1-59259-698-0_3

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5418-6

  • Online ISBN: 978-1-59259-698-0

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