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Receptors for Peptides of the VIP/PACAP and PYY/NPY/PP Families

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Book cover Gastrointestinal Endocrinology

Part of the book series: Contemporary Endocrinology ((COE,volume 8))

Abstract

Following the discovery of the first hormone, secretin, the digestive tract has been a major source for the isolation of new regulatory peptides (1). It is equipped with a diffuse endocrine tissue and is also richly innervated by extrinsic and intrinsic neurons, which synthesize and secrete a variety of regulatory peptides acting through endocrine, paracrine, and/or neurocrine pathways (2). Gut regulatory peptides affect functions of epithelia, muscles, nerves, endocrine cells, endothelial cells, immune cells, and so forth, by interacting with specific receptors located on the plasma membrane of target cells. Most of them transmit their signal via guanosine triphosphate (GTP)-binding protein-receptor coupling and thereby trigger changes of membrane-bound enzymes and second messenger levels (3,4).

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  1. Marc Laburthe PhD
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  2. Alain Couvineau PhD
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  3. Thierry Voisin PhD
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  1. Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA

    George H. Greeley Jr.

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Laburthe, M., Couvineau, A., Voisin, T. (1999). Receptors for Peptides of the VIP/PACAP and PYY/NPY/PP Families. In: Greeley, G.H. (eds) Gastrointestinal Endocrinology. Contemporary Endocrinology, vol 8. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-695-9_5

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