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Central Nervous System Diseases pp 131–151Cite as

Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism

Optimizing Behavioral Assessment of Outcome

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Parkinsonism has a complex and variable neuropathology and etiology (1,2), but the major common feature is progressive loss of dopamine (DA) neurons in the substantia nigra leading to motor impairment. Although understanding the initial causes and molecular mechanisms for degeneration of the nigrostriatal system would be invaluable for eventual treatment, in the meantime effective approaches to preventing the pathological and disabling clinical signs of the disorder may come from early detection and interventions that have quite general neuroprotective properties. Behavior-based diagnostic assessment aimed at detecting threshold level neuropathology would be critical, both in clinical practice and preclinically.

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Authors
  1. Timothy Schallert
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  2. Jennifer L. Tillerson
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Editors and Affiliations

  1. Alkermes, Inc., Cambridge, MA, USA

    Dwaine F. Emerich PhD (Director of Neuroscience) (Director of Neuroscience)

  2. Department of Neuroscience, Alkermes, Inc., Cambridge, MA, USA

    Reginald L. Dean III MS

  3. University of South Florida College of Medicine, Tampa, FL, USA

    Paul R. Sanberg PhD, DSc

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Schallert, T., Tillerson, J.L. (2000). Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism. In: Emerich, D.F., Dean, R.L., Sanberg, P.R. (eds) Central Nervous System Diseases. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-691-1_8

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