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The Senescence-Accelerated Mouse as a Possible Animal Model of Senile Dementia

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Central Nervous System Diseases

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Recent demographic trends toward a markedly aging population have led to concerns about more people developing age-associated diseases, in particular senile dementia. Therefore, it is important to clarify the basic mechanism of age-related changes in brain functions such as learning and cognitive deficiency and to develop safe and effective means of prevention and treatment of age-associated diseases. To do so, a useful animal model of age-associated diseases is essential. As one alternative model, Takeda et al. (1,2) developed the senescence-accelerated mouse (SAM) as a murine model of accelerated aging. SAM strains have a shortened life-span and develop early manifestations of senescence, including decreased activity, alopecia, lack of hair glossiness, skin coarseness, periophthalmic lesions, increased lordokyphosis, and systemic senile amyloidosis. The SAMP8 strain of senescence-related prone mice (SAMP) shows an age-related deterioration in learning ability compared with the control strain SAMR1, senescence-resistant mice (SAMR) (3–5). We studied neurochemical changes in the SAMP8 brain compared to the SAMR1 brain during aging (6,7) and the effectiveness of several drugs in preventing age-related changes in the SAMP8 brain. In this chapter, we report the neurochemical and pharmacological findings of a study of SAMP8 and SAMR1 mice and discuss the significance and limitations of SAMP8 in basic studies of the aging mechanism and the screening and development of novel cognitive enhancers.

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Authors
  1. Yasuyuki Nomura
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  2. Yasunobu Okuma
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  3. Yoshihisa Kitamura
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Editors and Affiliations

  1. Alkermes, Inc., Cambridge, MA, USA

    Dwaine F. Emerich PhD (Director of Neuroscience) (Director of Neuroscience)

  2. Department of Neuroscience, Alkermes, Inc., Cambridge, MA, USA

    Reginald L. Dean III MS

  3. University of South Florida College of Medicine, Tampa, FL, USA

    Paul R. Sanberg PhD, DSc

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© 2000 Springer Science+Business Media New York

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Nomura, Y., Okuma, Y., Kitamura, Y. (2000). The Senescence-Accelerated Mouse as a Possible Animal Model of Senile Dementia. In: Emerich, D.F., Dean, R.L., Sanberg, P.R. (eds) Central Nervous System Diseases. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-691-1_6

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  • DOI: https://doi.org/10.1007/978-1-59259-691-1_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-152-3

  • Online ISBN: 978-1-59259-691-1

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