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Heterologous Prime-Boost Vaccination in Tumor Immunotherapy

  • Michael J. Palmowski
  • Caroline Smith
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Most of the vaccine strategies under development use multiple immunizations with the same agent such as a viral vector encoding a tumor antigen. More recently, the concept of heterologous prime-boost immunization has been tested in animal models. This strategy involves the sequential administration of different delivery vectors encoding the same recombinant antigen (1). Initially demonstrated in animal studies of infectious diseases, such as malaria (1,2) and AIDS (3), prime-boost technology is now being developed for use in tumor patients (4).

Keywords

Delivery Vector Recombinant Antigen Semliki Forest Virus Recombinant Vaccinia Virus Immunotherapy Strategy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2004

Authors and Affiliations

  • Michael J. Palmowski
  • Caroline Smith

There are no affiliations available

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