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Melanoma Vaccines

  • Jeffrey Weber
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

The recent clinical experience with melanoma vaccines reflects a historical dichotomy. Current phase III trials have employed cellular vaccine strategies developed in the 1970s and have shown some hints of clinical benefit, whereas less developed but more rigorously derived strategies employing peptides, viral vectors encoding peptide sequences, and dendritic cells pulsed with peptides are still undergoing proof of concept phase I and II pilot trials and will not advance to the point of randomized phase III trials for some years to come. Over the next 5 yr, several large randomized cell vaccine trials will mature as we pursue newer ideas with peptide vaccines for melanoma based on molecular genetics and immunology. In this chapter I will describe recent evidence suggesting that a cell vaccine may generate a class I-restricted immune response to melanoma antigen peptides and may have utility in the adjuvant therapy of intermediate- and high-risk melanoma. This is followed by a description of the some of the most promising of the multitude of new peptide vaccine approaches available to patients with resected and metastatic melanoma today.

Keywords

Human Leukocyte Antigen Melanoma Patient Human Leukocyte Antigen Class Peptide Vaccine Melanoma Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2004

Authors and Affiliations

  • Jeffrey Weber

There are no affiliations available

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