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Melanoma Vaccines

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Book cover Handbook of Cancer Vaccines

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The recent clinical experience with melanoma vaccines reflects a historical dichotomy. Current phase III trials have employed cellular vaccine strategies developed in the 1970s and have shown some hints of clinical benefit, whereas less developed but more rigorously derived strategies employing peptides, viral vectors encoding peptide sequences, and dendritic cells pulsed with peptides are still undergoing proof of concept phase I and II pilot trials and will not advance to the point of randomized phase III trials for some years to come. Over the next 5 yr, several large randomized cell vaccine trials will mature as we pursue newer ideas with peptide vaccines for melanoma based on molecular genetics and immunology. In this chapter I will describe recent evidence suggesting that a cell vaccine may generate a class I-restricted immune response to melanoma antigen peptides and may have utility in the adjuvant therapy of intermediate- and high-risk melanoma. This is followed by a description of the some of the most promising of the multitude of new peptide vaccine approaches available to patients with resected and metastatic melanoma today.

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Authors
  1. Jeffrey Weber MD, PhD
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  1. Duke University Medical Center, Durham, NC, USA

    Michael A. Morse MD , Timothy M. Clay PhD  & H. Kim Lyerly MD ,  & 

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© 2004 Humana Press Inc.

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Weber, J. (2004). Melanoma Vaccines. In: Morse, M.A., Clay, T.M., Lyerly, H.K. (eds) Handbook of Cancer Vaccines. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-680-5_25

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  • DOI: https://doi.org/10.1007/978-1-59259-680-5_25

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9818-9

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