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Molecular Neuropharmacology pp 47–82Cite as

Molecular Pharmacology of the Metabotropic Glutamate Receptors

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Abstract

(S)-Glutamate (Glu) is the major excitatory neurotransmitter in the central nervous system (CNS), where it plays a key role in a wide range of brain functions, such as neural plasticity, memory formation, and neural development (1). On the other hand, Glu can also act as a neurotoxin under certain conditions, especially when energy supply is reduced. Excessive glutamatergic signaling has been implicated in acute neurotoxic insults such as ischemia, stroke, and epilepsy, and in multiple chronic neurodegenerative states like Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s chorea, and dementia. Furthermore, glutamatergic mechanisms have been proposed to contribute to psychiatric disorders like schizophrenia and anxiety, and modulation of glutamatergic transmission has been shown to be beneficial on certain forms of pain (2–4).

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  1. Anders A. Jensen
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  1. Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark

    Arne Schousboe PhD, DSc

  2. Department of Medical Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark

    Hans Bräuner-Osborne PhD, DSc

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Jensen, A.A. (2004). Molecular Pharmacology of the Metabotropic Glutamate Receptors. In: Schousboe, A., Bräuner-Osborne, H. (eds) Molecular Neuropharmacology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-672-0_3

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  • DOI: https://doi.org/10.1007/978-1-59259-672-0_3

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