AMPA Potentiation as a Treatment Option for Alzheimer’s Disease

  • Amy S. Chappell
  • Michael M. Witte
Part of the Current Clinical Neurology book series (CCNEU)


Alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) receptor modulators, although still in their infancy from a therapeutic standpoint, have the potential to correct the deficits associated with cognitive disorders such as Alzheimer’s disease (AD). This chapter reviews the AMPA receptor’s role in long-term potentiation and thus in learning and memory, and describes the AMPA potentiators currently under development.


Attention Deficit Hyperactivity Disorder Glutamate Receptor Attention Deficit Hyperactivity Disorder Synaptic Strength Nootropic Drug 
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© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Amy S. Chappell
  • Michael M. Witte

There are no affiliations available

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