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How Many Stem Cells Are Sufficient for Engraftment?

  • Chapter
Book cover Current Controversies in Bone Marrow Transplantation

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

The past 15 yr have witnessed an explosion of advances leading to important information regarding hematopoietic stem cells (HSCs), which has been directly applicable to the clinical setting. Mobilized peripheral blood (PB) and umbilical cord blood (CB) have been identified as alternatives to bone marrow (BM) as sources of human HSCs for clinical transplantation. Currently, BM remains the predominant stem cell source for allogeneic transplants (allotransplant); most autologous transplants (autotransplants) are now performed solely with mobilized PB stem cells (PBSC). Although experience with CB as a source of stem cells has been limited, it is expected to have its greatest application in the unrelated allotransplant setting. Recent observations that stem cells from each of these sources have biologically distinct properties, and that stem cell doses affect outcomes in clinical transplantation, underscore the importance of stem cell enumeration in predicting transplant outcomes.

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Authors
  1. Lynn C. O’Donnell PhD
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  2. Patrick J. Elder MS
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  3. Belinda R. Avalos MD
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Editors and Affiliations

  1. Bone Marrow Transplant Program, Department of Hematology/Medical Oncology, The Cleveland Clinic Foundation, Cleveland, OH, USA

    Brian J. Bolwell MD (Director, Staff Physician) (Director, Staff Physician)

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© 2000 Humana Press Inc., Totowa, NJ

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O’Donnell, L.C., Elder, P.J., Avalos, B.R. (2000). How Many Stem Cells Are Sufficient for Engraftment?. In: Bolwell, B.J. (eds) Current Controversies in Bone Marrow Transplantation. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-657-7_1

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  • DOI: https://doi.org/10.1007/978-1-59259-657-7_1

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