Overview
Early reports of therapeutic hypothermia for severe traumatic brain injury can be traced back to the first half of the 20th century. It is only within the last two decades that clinical studies have demonstrated that therapeutic moderate hypothermia for brief durations can improve patient outcomes following brain injury. The historical background, recent clinical experience, and mechanisms of action of moderate hypothermia are reviewed.
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Levy, E.I., Marion, D.W. (2004). Management of Traumatic Brain Injury with Moderate Hypothermia. In: Maier, C.M., Steinberg, G.K. (eds) Hypothermia and Cerebral Ischemia. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-653-9_8
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