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Nutrition and Immunity in the Elderly

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Diet and Human Immune Function

Part of the book series: Nutrition and Health ((NH))

Abstract

Within the past few years, a considerable amount of new information on the role of nutrition in the aging immune response has been published. This chapter is an update and expansion in scope of a chapter written by us and published in 2001 (1).

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References

  1. Bogden JD, Louria DB. Micronutrients and immunity in older people. In: Bendich A, Deckelbaum RJ (eds.). Preventive Nutrition: The Comprehensive Guide for Health Professionals (2nd ed.). Humana Press, Totowa, NJ, 2001, pp. 307–327.

    Google Scholar 

  2. Warner HR, Butler RN, Sprott RL, Schneider EL. Modern Biological Theories of Aging. Raven Press, New York, 1987.

    Google Scholar 

  3. Bendich A. Antioxidant micronutrients and immune responses. Ann NY Acad Sci 1990;587:168–180.

    PubMed  CAS  Google Scholar 

  4. Lesourd B, Mazari L. Nutrition and immunity in the elderly. Proc Nutr Soc 1999;58:685 – 695.

    PubMed  CAS  Google Scholar 

  5. Ben-Yehuda A, Weksler ME. Immune senescence: mechanisms and clinical implications. Cancer Invest 1992;10:525–531.

    PubMed  CAS  Google Scholar 

  6. Makinodan T. Patterns of age-related immunologic changes. Nutr Rev 1995;53:S27-S34.

    PubMed  CAS  Google Scholar 

  7. Effros RB, Walford RL. Infection and immunity in relation to aging. In: Goidl EA (ed.). Aging and the Immune Response. Marcel-Dekker, New York, 1987, pp. 45–65.

    Google Scholar 

  8. Bogden JD, Oleske JM, Munves EM, et al. Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. Am J Clin Nutr 1987;45:101–109.

    Google Scholar 

  9. Kuvibidilia S, Yu L, Ode D, Warner RP. The immune response in protein-energy malnutrition and single nutrient deficiencies. In: Klurfeld DM (ed.). Nutrition and Immunology. Plenum Press, New York, 1993, pp. 121–155.

    Google Scholar 

  10. Abbas AK, Lichtman AH, Pober JS. Cellular and Molecular Immunology. WB Saunders, Philadelphia, 1994, pp. 166–186.

    Google Scholar 

  11. Aronson M. Involution of the thymus revisited: immunological trade-offs as an adaptation to aging. Mech Ageing Dev 1993;72:49–55.

    PubMed  CAS  Google Scholar 

  12. Siskind GW. Aging and the immune system. In: Warner HR, Butler RN, Sprott RL, Schneider EL (eds.). Modern Biological Theories of Aging. Raven Press, New York, 1987, pp. 235–242.

    Google Scholar 

  13. Makinodan T, Kay MB. Age influence on the immune system. Adv Immunol 1980;29:287–330.

    PubMed  CAS  Google Scholar 

  14. Weksler ME. The senescence of the immune system. Hosp Prac 1981:53–64.

    Google Scholar 

  15. McMurray DN. Cell-mediated immunity in nutritional deficiency. Prog Food Nutr Sci 1984;8:193–228.

    PubMed  CAS  Google Scholar 

  16. Schwab R, Weksler ME. Cell biology of the impaired proliferation of T cells from elderly humans. In: Goidl EA (ed.). Aging and the Immune Response. Marcel Dekker, New York, 1987, pp. 67–80.

    Google Scholar 

  17. James SJ, Makinodan T. Nutritional intervention during immunologic aging: past and present. In: Armbrecht HJ, Prendergast JM, Coe RM (eds.). Nutritional Intervention in the Aging Process. Springer-Verlag, New York, 1984, pp. 209–227.

    Google Scholar 

  18. Meakins JL, Pietsch JB, Bubenick O, et al. Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma. Ann Surg 1977;186:241–250.

    PubMed  CAS  Google Scholar 

  19. Christou NV, Tellado-Rodriguez J, Chartrand L, et al. Estimating mortality risk in preoperative patients using immunologic, nutritional, and acute-phase response variables. Ann Surg 1989;210:69–77.

    PubMed  CAS  Google Scholar 

  20. Wayne SJ, Rhyne RL, Garry PJ, Goodwin JS. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J Gerontol 1990;45:M45-M48.

    PubMed  CAS  Google Scholar 

  21. Roberts-Thomson IC, Whittingham S, Youngchaiyud U, McKay IR. Aging, immune response, and mortality. Lancet 1974;2:368–370.

    PubMed  CAS  Google Scholar 

  22. Hicks MJ, Jones JF, Thies AC, Weigle KA, Minnich LL. Age-related changes in mitogen-induced lymphocyte function from birth to old age. Am J Clin Pathol 1983;80:159–163.

    PubMed  CAS  Google Scholar 

  23. Murasko DM, Nelson BJ, Silver R, Matour D, Kaye D. Immunologic response in an elderly population with a mean age of 85. Am J Med 1986;81:612–618.

    PubMed  CAS  Google Scholar 

  24. Markewitz A, Faist E, Lang S, et al. Successful restoration of cell-mediated immune response after cardiopulmonary bypass by immunomodulation. J Thorac Cardiovasc Surg 1993;105:15–24.

    PubMed  CAS  Google Scholar 

  25. Higa K, Noda B, Manabe H, Sato S, Dan K. T-lymphocyte subsets in otherwise healthy patients with herpes zoster and relationships to the duration of acute herpetic pain. Pain 1992;51:111–118.

    PubMed  CAS  Google Scholar 

  26. Stites DP. Clinical laboratory methods for detection of cellular immunity. In: Stites DP, Terr Al (eds.). Basic and Clinical Immunology (7th ed.). Appleton & Lange, Norwalk, CT, 1991, pp. 263–283.

    Google Scholar 

  27. Giorgi JV. Lymphocyte subset measurements: significance in clinical medicine. In: Rose NR, Friedman H, Fahey JL (eds.). Manual of Clinical Laboratory Immunology (3rd ed.). American Society for Microbiology, Washington, DC, 1986, pp. 236–246.

    Google Scholar 

  28. Sen P, Middleton JR, Perez G, et al. Host defense abnormalities and infection in older persons. Infect Med 1994;11:364–370.

    Google Scholar 

  29. Perskin MH, Cornstein BN. Age-related changes in neutrophil structure and function. Mech Ageing Dev 1992;64:303–313.

    PubMed  CAS  Google Scholar 

  30. Nagel JE, Han K, Coon PJ, Adler WH, Bender BS. Age differences in phagocytosis by polymorphonuclear leukocytes measured by flow cytometry. J Leukoc Biol 1986;39:399–407.

    PubMed  CAS  Google Scholar 

  31. Shoham-Kessary H, Gershon H. Impaired reactivity to inflammatory stimuli of neutrophils from elderly donors. Aging Immunol Infect Dis 1992;3:169–183.

    Google Scholar 

  32. Corberand J, Ngyen F, Laharrague P, et al. Polymorphonuclear functions and aging in humans. J Am GeriatrSoc 1981;29:391–397.

    CAS  Google Scholar 

  33. Makinodan T, Lubinski J, Fong TC. Cellular, biochemical, and molecular basis of T-cell senescence. Arch Pathol Lab Med 1987;111:910–914.

    PubMed  CAS  Google Scholar 

  34. Rubin LA, Nelson DL. The soluble interleukin-2 receptor: biology, function, and clinical application. Ann Intern Med 1990;113:619–627.

    PubMed  CAS  Google Scholar 

  35. Manoussakis MN, Papadopoulos GK, Drosos AA, Moutsopoulos HM. Soluble interleukin-2 receptor molecules in the serum of patients with autoimmune diseases. Clin Immunol Immunopathol 1989;50:321–332.

    PubMed  CAS  Google Scholar 

  36. Lahat N, Shriller R, Zlotnick AY, Merin G. Early IL-2/sIL-2R surge following surgery leads to temporary immune refractoriness. Clin Exp Immunol 1993;92:482–486.

    PubMed  CAS  Google Scholar 

  37. Bogden JD, Kemp FW, Liberatore BL, et al. Serum interleukin-2 receptor concentrations, physical activity, and micronutrient nutrition in older people. J Cell Biochem 1993;17B:86.

    Google Scholar 

  38. Sansoni P, Brianti V, Fagnoni F. NK cell activity and T-lymphocyte proliferation in healthy centenarians. Ann NY Acad Sci 1992;663:505–507.

    PubMed  CAS  Google Scholar 

  39. Mariotti S, Sansoni P, Barbesino G, et al. Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet 1992;339:1506–1508.

    PubMed  CAS  Google Scholar 

  40. Scrimshaw NS, SanGiovanni JP. Synergism of nutrition, infection, and immunity: an overview. Am J Clin. Nutr 1997;66:464S–477S.

    PubMed  CAS  Google Scholar 

  41. Fraker P. Nutritional immunology: methodological considerations. J Nutr Immunol 1994;2:87–92.

    Google Scholar 

  42. Chandra RK. Nutrition and immunity. Contemp Nutrition 1986;11:1–4.

    Google Scholar 

  43. Chandra RK. Immunodeficiency in undernutrition and overnutrition. Nutr Rev 1981;39:225–231.

    PubMed  CAS  Google Scholar 

  44. McMurray DN, Loomis S A, Casazza LJ, Rey H, Miranda R. Development of impaired cell-mediated immunity in mild and moderate malnutrition. Am J Clin Nutr 1981;34:68–77.

    PubMed  CAS  Google Scholar 

  45. Dowd PS, Heatley RV. The influence of undernutrition on immunity. Clin Sci 1984;66:241–248.

    PubMed  CAS  Google Scholar 

  46. Beisel WR. Single nutrients and immunity. Am J Clin Nutr 1982;35:417–468.

    PubMed  CAS  Google Scholar 

  47. Beisel WR. Nutrition and infection. In: Linder MC (ed.). Nutritional Biochemistry and Metabolism. Elsevier, New York, 1985, pp. 369–394.

    Google Scholar 

  48. Bogden JD, Kemp FW, Han S, et al. Status of selected nutrients and progression of human immunodeficiency virus type 1 infection. Am J Clin Nutr 2000;72:809–815.

    PubMed  CAS  Google Scholar 

  49. Goodwin JS, Garry PJ. Relationships between megadose vitamin supplementation and immunological function in a healthy elderly population. Clin Exp Immunol 1983;51:647–653.

    PubMed  CAS  Google Scholar 

  50. Goodwin JS, Garry PJ. Lack of correlation between indices of nutritional status and immunologic function in elderly humans. J Gerontol 1988;43:M46-M49.

    PubMed  CAS  Google Scholar 

  51. Kawakami K, Kadota J, Iida K, et al. Reduced immune function and malnutrition in the elderly. Tohoku J Exper Med 1999;187:157–171.

    CAS  Google Scholar 

  52. Kemp FW, DeCandia J, Li W, et al. Relationships between immunity and dietary and serum antioxidants, B vitamins, and homocysteine in elderly men and women. Nutr Res 2002;22:45–53.

    CAS  Google Scholar 

  53. Jacob RA, Kelley DS, Pianalto FS, et al. Immunocompetence and oxidant defense during ascorbate depletion of healthy men. Am J Clin Nutr 1991;54:1302S-1309S.

    PubMed  CAS  Google Scholar 

  54. Fuller CJ, Faulkner H, Bendich A, Parker RS, Roe DA. Effect of beta-carotene supplementation on photosuppression of delayed-type hypersensitivity in normal young men. Am J Clin Nutr 1992;56: 684–690.

    PubMed  CAS  Google Scholar 

  55. Herraiz L, Rahman A, Paker R, Roe D. The role of beta-carotene supplementation in prevention of photosuppression of cellular immunity in elderly men. FASEB J 1994;8:A423.

    Google Scholar 

  56. Herraiz LA, Hsieh WC, Parker RS, et al. Effect of UV exposure and b-carotene supplementation on delayed-type hypersensitivity response in healthy older men. J Am Coll Nutr 1998;17:617–624.

    PubMed  CAS  Google Scholar 

  57. Watson RR, Prabhala RH, Plezia PM, Alberts DS. Effect of beta-carotene on lymphocyte subpopula-tions in elderly humans: evidence for a dose-response relationship. Am J Clin Nutr 1991;53:90–94.

    PubMed  CAS  Google Scholar 

  58. Santos MS, Meydani SN, Leka L, et al. Natural killer cell activity in elderly men is enhanced by P-carotene supplementation. Am J Clin Nutr 1996;64:772–777.

    PubMed  CAS  Google Scholar 

  59. Omenn GS, Goodman GE, Thornquist MD, et al. Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Instit 1996;88:1550–1559.

    CAS  Google Scholar 

  60. Albanes D, Heinonen OP, Taylor PR, et al. Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of baseline characteristics and study compliance. J Natl Cancer Inst 1996;88:1560–1570.

    PubMed  CAS  Google Scholar 

  61. Talbott MC, Miller LT, Kerkvliet NI. Pyridoxine supplementation: effect on lymphocyte responses in elderly persons. Am J Clin Nutr 1987;46:659–664.

    PubMed  CAS  Google Scholar 

  62. Meydani SN, Ribaya-Mercado JD, Russell RN, et al. Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr 1991;53:1275–1280.

    PubMed  CAS  Google Scholar 

  63. Rail LC, Meydani SN. Vitamin B6 and immune competence. Nutr Rev 1993;51:217–225.

    Google Scholar 

  64. Meydani SN, Meydani M, Blumberg JB, et al. Vitamin E supplementation and the in vivo immune response in healthy elderly subjects. JAMA 1997;277:1380–1386.

    PubMed  CAS  Google Scholar 

  65. Pallast EG, Schouten EG, de Waart FG, et al. Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr 1999;69:1273–1281.

    PubMed  CAS  Google Scholar 

  66. Oleske JM, Westphal ML, Shore S, et al. Correction with zinc therapy of depressed cellular immunity in acrodermatitis enteropathica. Am J Dis Child 1979;133:915–918.

    PubMed  CAS  Google Scholar 

  67. Fraker PJ, Gershwin ME, Good RA, Prasad A. Interrelationships between zinc and immune function. Fed. Proc 1986;45:1474–1479.

    PubMed  CAS  Google Scholar 

  68. Bogden JD, Oleske JM, Lavenhar MA, et al. Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. Am J Clin Nutr 1988;48:655–663.

    PubMed  CAS  Google Scholar 

  69. Chandra RK, Hambreaus L, Puri S, Au B, Kutty KM. Immune responses of healthy volunteers given supplements of zinc or selenium. FASEB J 1993;7:A723.

    Google Scholar 

  70. Doherty CP, Kashein MA, Shakur MS, et al. Zinc and rehabilitation from severe protein-energy malnutrition: higher-dose regimens are associated with increased mortality. Am J Clin Nutr 1998; 68:742–748.

    PubMed  CAS  Google Scholar 

  71. Bogden JD, Oleske JM, Lavenhar MA, et al. Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. J Am College Nutr 1990;9:214–225.

    CAS  Google Scholar 

  72. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992;340:1124–1127.

    PubMed  CAS  Google Scholar 

  73. Penn ND, Purkins L, Kelleher J, et al. The effect of dietary supplementation with vitamins A, C, and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age Ageing 1991;20:169–174.

    PubMed  CAS  Google Scholar 

  74. Chavance M, Herbeth B, Lemoine A, Zhu BP. Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial. Intl J Vit Nutr Res 1993;63:11–16.

    CAS  Google Scholar 

  75. Bogden JD, Bendich A, Kemp FW, et al. Daily micronutrient supplements enhance delayed-hypersen-sitivity skin test responses in older people. Am J Clin Nutr 1994;60:437–447.

    PubMed  CAS  Google Scholar 

  76. Kniker WT, Anderson CT, McBryde JL, Roumiantzeff M, Lesourd B. Multitest CMI for standardized measurement of delayed cutaneous hypersensitivity and cell-mediated immunity. Normal values and proposed scoring system for healthy adults in the USA. Ann Allergy 1984;52:75–82.

    PubMed  CAS  Google Scholar 

  77. Girodon F, Galan P, Monget AL, et al. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients. Arch Intern Med 1999;159:748–754.

    PubMed  CAS  Google Scholar 

  78. Park YK, Kim I, Yetley EA. Characteristics of vitamin and mineral supplement products in the United States. Am J Clin Nutr 1991;54:750–759.

    PubMed  CAS  Google Scholar 

  79. Block G, Cox C, Madans J, et al. Vitamin supplement use, by demographic characteristics. Am J Epidemiol 1988;127:297–309.

    PubMed  CAS  Google Scholar 

  80. Cooper EL., Stress, Immunity, and Aging. Marcel-Dekker, New York, 1984.

    Google Scholar 

  81. Solomon GF. Emotions, immunity, and disease. In: Copper EL (ed.). Stress, Immunity and Aging. Marcel Dekker, New York, 1984, pp. 1–10.

    Google Scholar 

  82. Watson RR, Eisinger M. Exercise and Disease. CRC, Boca Raton, FL, 1992, pp. 71–178.

    Google Scholar 

  83. Keast D, Cameron K, Morton AR. Exercise and the immune response. Sports Med 1988;5:248–267.

    PubMed  CAS  Google Scholar 

  84. Fry RW, Morton AR, Keast D. Overtraining in athletes. Sports Med 1991;12:32–65.

    PubMed  CAS  Google Scholar 

  85. Nieman DC, Johanssen LM, Lee JW, Arabatzis K. Infectious episodes in runners before and after the Los Angeles marathon. J Sports Med Phys Fitness 1990;30:316–328.

    PubMed  CAS  Google Scholar 

  86. Peters EM, Bateman ED. Ultramarathon running and upper respiratory tract infections. S Africa Med J 1983;64:582–584.

    CAS  Google Scholar 

  87. Barry-Billings M, Blomstrand E, McAndrew N, Newsholme EA. A communication link between skeletal muscle, brain, and cells of the immune system. Int J Sports Med 1990;11:S122-S128.

    Google Scholar 

  88. Rubenoff R, Rail LC. Humoral mediation of changing body composition during aging and chronic inflammation. Nutr Rev 1993;51:1–11.

    Google Scholar 

  89. Meydani S. Dietary modulation of cytokine production and biologic functions. Nutr Rev 1990;48: 361–368.

    PubMed  CAS  Google Scholar 

  90. Nieman DC. Exercise immunology: future directions for research related to athletics, nutrition, and the elderly. Int J Sports Med 2000;21(Suppl 1):S61-S68.

    PubMed  CAS  Google Scholar 

  91. Paw MJ, deJong N, Pallast EG, et al. Immunity in frail elderly: a randomized controlled trial of exercise and enriched foods. Med Sci Sports Exer 2000;32:2005–2011.

    Google Scholar 

  92. Stallone DD. The influence of obesity and its treatment on the immune system. Nutr Rev 1994;52: 37–50.

    PubMed  CAS  Google Scholar 

  93. Spear-Hartley A, Sherman AR. Food restriction and the immune system. J Nutr Immunol 1994;3: 27–50.

    Google Scholar 

  94. Eaton SB, Eaton SB III, Konner MJ, Shostak M. An evolutionary perspective enhances understanding of human nutritional requirements. J Nutr 1996;126:1732–1740.

    PubMed  CAS  Google Scholar 

  95. Olshansky SJ, Carnes BA, Grahn D. Confronting the boundaries of human longevity. Am Scientist 1998;86:52–61.

    Google Scholar 

  96. Goodwin JS. Decreased immunity and increased morbidity in the elderly. Nutr Rev 1995;53:S41-S46.

    PubMed  CAS  Google Scholar 

  97. Rimm EB, Stampfer MJ, Ascherio A, et al. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450–1456.

    PubMed  CAS  Google Scholar 

  98. Stampfer MJ, Hennekens CB, Manson JE, et al. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993;328:1444–1449.

    PubMed  CAS  Google Scholar 

  99. Bendich A, Langseth L. Health effects of vitamin C supplementation: a review. J Am Coll Nutr 1995; 14:124–136.

    PubMed  CAS  Google Scholar 

  100. Graat JM, Sohouten EG, Kok FJ. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons. JAMA 2002;288:715–721.

    PubMed  CAS  Google Scholar 

  101. US Preventive Services Task Force. Routine vitamin supplementation to prevent cancer and cardiovascular disease: recommendations and rationale. Ann Intern Med 2003;139:51–55.

    Google Scholar 

  102. Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in adults. JAMA 2002;287: 3116–3129.

    PubMed  CAS  Google Scholar 

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Bogden, J.D., Louria, D.B. (2004). Nutrition and Immunity in the Elderly. In: Hughes, D.A., Darlington, L.G., Bendich, A. (eds) Diet and Human Immune Function. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-652-2_5

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  • DOI: https://doi.org/10.1007/978-1-59259-652-2_5

  • Publisher Name: Humana Press, Totowa, NJ

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