Separation Problems

Band Tailing and Peak Distortion
  • John W. Dolan
  • Lloyd R. Snyder


Preceding chapters examined problems that can be traced to the equipment or materials (modules, columns, solvents, etc.) used in carrying out the LC separation. In this and the next three chapters we will discuss some other kinds of system failure. Whereas our previous troubleshooting has been mainly physical or mechanical in nature, the origins of the problems we will now examine are often in the chemistry of the system. And because chemistry is still largely an experimental science, these kinds of problems usually are harder to solve. However, most chromatographers have a good background in chemistry or biochemistry— and all that is required in most cases is to put this training to use.


Silanol Group Buffer Concentration Separation Problem Sample Compound Octyl Amine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • John W. Dolan
    • 1
  • Lloyd R. Snyder
    • 1
  1. 1.LC Resources Inc.Walnut CreekUSA

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