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Gene Therapy for Neurological Disorders and Brain Tumors pp 39–52Cite as

Characteristics of Adenovirus Vectors

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Adenovirus vectors have shown seductive promise as molecular biology tools and are being proposed for a number of clinical gene delivery applications. We will review the properties of adenovirus vectors that are responsible for the great interest in their use. We will discuss a number of the limitations of the current vectors and describe some of the strategies that are being used to improve these vectors.

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Authors
  1. Susanna Chiocca
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  2. Matt Cotten
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Editors and Affiliations

  1. Molecular Neuro-Oncology, Neurosurgical Service, Massachussetts General Hospital, Harvard Medical School, Boston, MA, USA

    E. Antonio Chiocca MD, PhD

  2. Neurogenetics Unit, Massachussetts General Hospital, Harvard Medical Center, Boston, MA, USA

    Xandra O. Breakefield PhD

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Chiocca, S., Cotten, M. (1998). Characteristics of Adenovirus Vectors. In: Chiocca, E.A., Breakefield, X.O. (eds) Gene Therapy for Neurological Disorders and Brain Tumors. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-478-8_2

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  • DOI: https://doi.org/10.1007/978-1-59259-478-8_2

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