Evidence for and Mechanism of Action of Neurotoxicity of Amphetamine Related Compounds

  • R. Lew
  • J. E. Malberg
  • George A. Ricuarte
  • Lewis S. Seiden
Part of the Contemporary Neuroscience book series (CNEURO)


The purpose of this chapter is to review the evidence that substituted amphetamines (AMPHs), such as methamphetamine (METH), have neurotoxic potential, discuss critical determinants of AMPH neurotoxicity, and consider possible mechanisms underlying the neurotoxic action of AMPH and some of its derivatives. This evidence indicates that METH, AMPH, methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), m-trifluoromethyl-N-ethylamphetamine fenfluramine (FEN), and the combination of phentermine (PHEN) and FEN can cause long-lasting deficits in brain dopamine (DA) and/or serotonin (5HT) systems. For many of these drugs, the pharmacological properties are quite similar across species, including humans. Therefore, the possibility that the neurotoxic effects of AMPH derivatives may generalize from nonhuman mammals to humans must be considered.


Glial Fibrillary Acidic Protein Quinolinic Acid Uptake Site Tryptophan Hydroxylase Activity Mdma Neurotoxicity 
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© Springer Science+Business Media New York 1998

Authors and Affiliations

  • R. Lew
  • J. E. Malberg
  • George A. Ricuarte
  • Lewis S. Seiden

There are no affiliations available

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