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Molecular Mechanisms of Action of 5,6- and 5,7-Dihydroxytryptamine

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Highly Selective Neurotoxins

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Disruption of neuronal function has frequently been employed to obtain morphological, physiological, biochemical, and behavioral information about different neuronal types and pathways. Surgical or electrolytic denervation of particular neurotransmitter systems represents methods to accomplish such disruptions. However, in an organ as complex as the brain, these techniques suffer from inherent limitations particularly with respect to selectivity. In the mid-1960s, several groups reported that a hydroxylated analog of the neurotransmitter dopamine (DA), namely 6-hydroxydopamine (6-OHDA), induced degeneration of peripheral and central nerve terminals that was remarkably selective for catecholaminergic (particularly noradrenergic) neurons (1–3). This discovery introduced the concept of chemical lesioning to the fields of neurochemical and neurobiological research.

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Authors
  1. Tahereh Tabatabaie
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  2. Glenn Dryhurst
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Editors and Affiliations

  1. Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA

    Richard M. Kostrzewa

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Tabatabaie, T., Dryhurst, G. (1998). Molecular Mechanisms of Action of 5,6- and 5,7-Dihydroxytryptamine. In: Kostrzewa, R.M. (eds) Highly Selective Neurotoxins. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-477-1_10

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  • DOI: https://doi.org/10.1007/978-1-59259-477-1_10

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