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Molecular Mechanisms of Dementia pp 21–37Cite as

Potential Biological Mechanisms of ApoE in Alzheimer’s Disease

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Other chapters in this book discuss the three genes involved in the development of early onset forms of AD: APP, presenilin-1, and presenilin-2. These genes share a number of features. First, mutations in these genes lead to early onset-forms of AD. Second, mutations in these genes invariably lead to AD; i.e., they are completely penetrant. Third, the functions of the APP, presenilin-1, and presenilin-2 gene products are unknown. In order to determine the functions of these genes, considerable research is being invested in examining the distribution of these proteins, the regulation of their expression, and the identification of proteins that interact with them.

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  1. G. William Rebeck
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  1. Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

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Rebeck, G.W. (1997). Potential Biological Mechanisms of ApoE in Alzheimer’s Disease. In: Wasco, W., Tanzi, R.E. (eds) Molecular Mechanisms of Dementia. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-471-9_2

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  • DOI: https://doi.org/10.1007/978-1-59259-471-9_2

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