Abstract
Neurons and glial cells in the central nervous system (CNS) are embedded in a highly regulated microenvironment (Nicholson, 1995). The composition of this interstitial fluid is determined by secretion of the capillaries constituting the blood-brain barrier and of cerebrospinal fluid (which is in diffusion equilibrium with the interstitial milieu) by the choroid plexus. This equilibrium is perturbed by impulse and synaptic activity of neurons (Frankenhaeuser and Hodgkin, 1956). Such activity results in changes in the levels of extracellular ions, in particular of K+ (aKe), as well as of neurotransmitters or other neuroactive substances (Sykova, 1983; Dietzel et al., 1989; Walz, 1989). These disturbances are prominent during pathological processes like epilepsy or hypoxia (Hansen, 1985; Heinemann, 1995; Nicholson, 1995; Richter and Ballanyi, 1995).
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Ballanyi, K. (1995). Functional Role of Ion Transporters and Neurotransmitter Receptors in Glia. In: Vernadakis, A., Roots, B.I. (eds) Neuron—Glia Interrelations During Phylogeny. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-468-9_8
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DOI: https://doi.org/10.1007/978-1-59259-468-9_8
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