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Experimental Epilepsy Induced By Direct Topical Placement of Chemical Agents on the Cerebral Cortex

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Neurotransmitters and Epilepsy

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

An almost endless variety of agents, when applied directly to the surface of the brain, are capable of producing convulsions. The most important compounds were last methodically reviewed by Ward (1972) and Prince (1972). Some of these agents produce convulsions that are immediate in onset, whereas with others there is a delay before the appearance of seizures. The convulsive episodes produced by several compounds last for only a few minutes, although the seizure states produced by others persist for the life of the animal. Some agents produce seizures in only certain species, whereas others produce convulsions in all species that have been examined. These variations should be taken into consideration when neurochemical factors responsible for the epileptogenic state are assessed, and they will be addressed in this chapter.

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Authors
  1. Charles R. Craig
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  2. Brenda K. Colasanti
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Editors and Affiliations

  1. Department of Basic Sciences, College of Medicine at Peoria, University of Illinois, Peoria, Illinois, USA

    Phillip C. Jobe

  2. Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

    Hugh E. Laird II

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Craig, C.R., Colasanti, B.K. (1987). Experimental Epilepsy Induced By Direct Topical Placement of Chemical Agents on the Cerebral Cortex. In: Jobe, P.C., Laird, H.E. (eds) Neurotransmitters and Epilepsy. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-462-7_8

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  • DOI: https://doi.org/10.1007/978-1-59259-462-7_8

  • Publisher Name: Humana Press, Totowa, NJ

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