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The Genetically Epilepsy-Prone Rat

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Neurotransmitters and Epilepsy

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

One of the key elements in developing a treatment for any disorder is understanding its cause. As simple and logical as that statement sounds, it nevertheless represents the major obstacle to providing effective therapy in most disorders. Indeed, such is the case for the neurological disorder called epilepsy. In part, this can be explained by the fact that epilepsy is not a specific disease, but a family of neurological disorders that is defined by the clinical symptoms displayed by the patient. The plethora of symptoms observed in epilepsy is the result of the seizure process affecting different brain regions. The fact that different areas of the central nervous system can be and are affected suggests a multifactorial cause for this family of seizure disorders.

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References

  • Berridge, M. J., Downes, C. P., and Hanley, M. R.: Lithium amplifies agonist dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206: 587–595, 1982.

    PubMed  CAS  Google Scholar 

  • Bonhaus, D. W. and Huxtable, R. J.: Seizure-susceptibility and decreased taurine transport in the genetically epileptic rat. Neurochem. Int. 6(3): 365–368, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Bonhaus, D., Laird, H. E., and Huxtable, R. J.: Decreased taurine transport in epileptic rats. Proc. West. Pharmacol. Soc. 25: 25–28, 1982.

    PubMed  CAS  Google Scholar 

  • Bonhaus, D. W., Laird, H. E., Mimaki, T., Yamamura, H. I., and Huxtable, R. J.: Possible Bases for the Anti-Convulsant Action of Taurine, In: Sulfur Amino Acids Biochemical and Clinical Aspects (K. Kuriyama, R. J. Huxtable, and H. I. Wata, eds.) Liss, New York, 1983.

    Google Scholar 

  • Booker, J. G., Jobe, P. C., Dailey, J. W., and Lane, J. D.: Cortical GAB Areceptors in the genetically epilepsy prone rat. Fed. Proc. 42: 365 (abst.), 1983.

    Google Scholar 

  • Booker, J. G., Dailey, J. W., Jobe, P. C., and Lane, J. D.: Cerebral cortical GABA and benzodiazepine binding sites in genetically seizure prone rats. Life Sci. 1986 (accepted for publication).

    Google Scholar 

  • Bourn, W. M.: Modulation of audiogenic seizures by cortical norepinephrine in the rat (doctoral dissertation). Tuscon, University of Arizona, 1974.

    Google Scholar 

  • Bourn, W. M., Chin, L., and Picchioni, A. L.: Enhancement of audiogenic seizure by 6-hydroxydopamine. J. Pharm. Pharmacol. 24: 913–914, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Bourn, W. M., Chin, L., and Picchioni, A. L.: Effect of neonatal 6-hydroxydopamine treatment on audiogenic seizures. Life Sci. 21: 701–705, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Bourn, W. M., Chin, L., and Picchioni, A. L.: The role of dopamine in sound-induced convulsions. J. Pharm. Pharmacol. 30: 800–801, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Bourn, W. M. and Garrett, R. L.: Increased susceptibility of audiogenic rats to barbital withdrawl convulsions. Pharmacol. Biochem. Behav. 19: 839–841, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Brown, E., Kendall, D. A., and Nahorski, S. R.: Inositol phospholipid hydrolysis in rat cerebral cortical slices: 1. Receptor characterization. J. Neurochem. 42: 1379–1387, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Browning, R. A., Nelson, D. K., Mogharreban, N., Jobe, P. C., and Laird II, H. E.: Effect of midbrain and pontine tegmental lesions on audiogenic seizures in genetically epilepsy-prone rats. Epilepsia 26(2): 175–183, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Consroe, P., Kudray, K., and Schmitz, R.: Acute and chronic antiepileptic drug effects in audiogenic seizure-susceptible rats. Exp. Neurol. 70: 626–637, 1980.

    Article  PubMed  CAS  Google Scholar 

  • Consroe, P. C., Picchioni, A. L., and Chin, L.: Audiogenic seizure susceptible rats. Fed. Proc. 38: 2411–2416, 1979.

    PubMed  CAS  Google Scholar 

  • Croucher, M. J., Collins, J. F., and Meldrum, B. S.: Anticonvulsant action of excitatory amino acid antagonists. Science 21: 899–901, 1982.

    Article  Google Scholar 

  • Dailey, J. W. and Jobe, P. C.: Noradrenergic abnormalities in the genetically epilepsy-prone rat: Do they cause or result from seizures? Soc. Neurosci. 9(1): 400, 1983.

    Google Scholar 

  • Dailey, J. W. and Jobe, P. C.: Anticonvulsant drugs and the genetically epilepsy-prone rat. Fed. Proc. 44: 2640–2644, 1985.

    PubMed  CAS  Google Scholar 

  • Dailey, J. W., Battarbee, H. D., and Jobe, P. C.: Enzyme activities in the central nervous system of the epilepsy-prone rat. Brain Res. 231: 225–230, 1982.

    Article  PubMed  CAS  Google Scholar 

  • Dailey, J. W., Reigel, C. E., Jr., Ko, K. H., Acurio, M. T., Penny, J. E., and Jobe, P. C.: Abnormalities in brain norepinephrine levels in genetically epilepsy-prone rats. Soc. Neurosci. (Absts.), 11: 1316, 1985a.

    Google Scholar 

  • Dailey, J. W., Reigel, C. E., Jr., Woods, T. W., Penny, J. E., and Jobe, P. C.: Types of serotonergic abnormalities characteristic of genetically epilepsy-prone rats (GEPRs). Fed. Proc. 44: 1107, 1985b.

    Google Scholar 

  • DeFeudis, F. V.: Central glycine-receptors. Gen. Pharmacol. 9: 139–144, 1978.

    Article  Google Scholar 

  • Duplisse, B. R.: Mechanism of susceptibility of rats to audiogenic seizure (doctoral dissertation). Tucson, University of Arizona, 1976.

    Google Scholar 

  • Duplisse, B. R., Picchioni, A. L., Chin, L., and Consroe, P.: Electroshock seizure thresholds: Differences between audiogenic and non-audiogenic rats. J. Int. Res. Commun.1: 9, 1973.

    Google Scholar 

  • Ebadi, M., Jobe, P. C., and Laird II, H. E.: Variation of pyridoxal phosphate and pyridoxal kinase in brains of genetically epilepsyprone rats. Epilepsia 26: 353–359, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Emson, P. C.: Biochemical and Metabolic Changes in Epilepsy, In: Taurine and Neurological Disorders (A. Barbeau and R. J. Huxtable, eds.) Raven, New York, 1978.

    Google Scholar 

  • Gehlback, G. and Faingold, C. L.: Audiogenic seizures and effects of GABA and benzodiazepines on inferior colliculus neurons in the genetically epilepsy prone rat. Neurosci. Abst.10: 569, 1984.

    Google Scholar 

  • Huxtable, R. J. and Laird II, H. E.: Are amino acid patterns necessarily abnormal in epileptic brains? Studies on the genetically seizuresusceptible rat. Neurosci. Lett. 10: 341–345, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Huxtable, R. J., Laird, H., Bonhaus, D., and Thies, A. C.: Correlations between amino acid concentrations in brains of seizure-susceptible and seizure-resistant rats. Neurochem. Int. 4(1): 73–78, 1982.

    Article  PubMed  CAS  Google Scholar 

  • Jobe, P. C.: Relationship of brain metabolism to audiogenic seizure in the rat (doctoral dissertation). Tucson, University of Arizona, 1970.

    Google Scholar 

  • Jobe, P. C.: Pharmacology of Audiogenic Seizures, In: The Pharmacology of Hearing: Experimental and Clinical Bases(R. D. Brown and E. A. Daigneault, eds.) Wiley, New York, 1981.

    Google Scholar 

  • Jobe, P. C., Brown, R. D., and Dailey, J. W.: Effect of Ro 4–1284 on audiogenic seizure susceptibility and intensity in epilepsy-prone rats. Life Sci. 28: 2031–2038, 1981.

    Article  PubMed  CAS  Google Scholar 

  • Jobe, P. C. and Laird II, H. E.: Neurotransmitter abnormalities as determinants of seizure susceptibility and intensity in the genetic models of epilepsy. Biochem. Pharmacol. 30: 3137–3144, 1981.

    Article  PubMed  CAS  Google Scholar 

  • Jobe, P. C., Laird II, H. E., and Dailey, J. W.: Innate abnormalities in CNS serotonin concentrations in genetically epilepsy-prone rats (GEPRs). Absts. Soc. Neurosci. 9: 399, 1983.

    Google Scholar 

  • Jobe, P. C., Laird II, H. E., Ko, K. H., Ray, T., and Dailey, J. W.: Abnormalities in monoamine levels in the central nervous system of the genetically epilepsy-prone rat. Epilepsia 23: 359–366, 1982a.

    Article  PubMed  CAS  Google Scholar 

  • Jobe, P. C., Laird II, H. E., Woods, T. W., and Dailey, J. W.: Noradrenergic abnormalities in two independently developed strains of genetically epilepsy-prone rats. Neurosci. Abst. 8: 1982b.

    Google Scholar 

  • Jobe, P. C., Picchioni, A. L., and Chin, L.: Role of brain norepinephrine on audiogenic seizure in the rat. . Pharmacol. Exp. Ther. 184: 1–10, 1973a.

    CAS  Google Scholar 

  • Jobe, P. C., Picchioni, A. L., and Chin, L.: Role of brain 5-hydroxytryptamine in audiogenic seizure in the rat. Life Sci.13: 1–13, 1973b.

    Article  PubMed  CAS  Google Scholar 

  • Jobe, P. C., Ko, K. H., and Dailey, J. W.: Abnormalities in norepinephrine turnover rate in the central nervous system of the genetically epilepsy-prone rat. Brain Res. 290: 357–360, 1984a.

    Article  PubMed  CAS  Google Scholar 

  • Jobe, P. C., Woods, T. W., and Dailey, J. W.: Catecholamine concentrations in the hippocampus, striatum, and the remaining telencephalon of the genetically epilepsy-prone rat (GEPR). Neuro. Abs. 10: 409, 1984b.

    Google Scholar 

  • Jobe, P. C., Woods, T. W., Reigel, C. E., and Dailey, J. W.: Biogenic amine concentrations in the hypothalamus of the genetically epilepsy-prone rat (GEPR). Pharmacologist 26(3): 220, 1984c.

    Google Scholar 

  • Jobe, P. C., Reigel, C. E., Jr., Woods, T. W., Penny, J. E., and Dailey, J. W.: Do noradrenergic deficits in the genetically epilepsy-prone rat (GEPR) correlate with seizure susceptibility or severity? Fed. Proc. 44: 1107, 1985.

    Google Scholar 

  • Ko, K.: Monoamine transmission in the regulation of seizures in genetically epilepsy-prone rat (doctoral dissertation). Shreveport, Louisiana State University, 1981.

    Google Scholar 

  • Ko, K., Dailey, J. W., and Jobe, P. C.: Effects of increments in norepinephrine concentrations on seizure intensity in the genetically epilepsyprone rats. J. Pharmacol. Exp. Ther. 222: 662–669, 1982.

    PubMed  CAS  Google Scholar 

  • Ko, K., Dailey, J. W., and Jobe, P. C.: Seizure intensity changes caused by adrenergic agonists in genetically epilepsy-prone rats (GEPR). Fed. Proc. 42: 364, 1983.

    Google Scholar 

  • Laird II, H. E.: 5-Hydroxytryptamine as an inhibitory modulator of audiogenic seizures (doctoral dissertation). Tucson, University of Arizona, 1974.

    Google Scholar 

  • Laird II, H. E.: Abnormal concentrations and turnover rates of norepinephrine and dopamine in brains of genetically seizure-susceptible rats. Epilepsia 24: 107, 1983.

    Google Scholar 

  • Laird, H. E., Chin, L., and Picchioni, A. L.: Enhancement of audiogenic seizure intensity by p-chloromethamphetamine. Proc. West. Pharmacol. Soc. 17: 46–50, 1974.

    CAS  Google Scholar 

  • Laird, H. E., Dailey, J. W., and Jobe, P. C.: Innate abnormalities in norepinephrine levels in genetically epilepsy-prone rats (GEPRs). Fed. Proc. 42: 363, 1983.

    Google Scholar 

  • Laird II, H. E., Dailey, J. W., and Jobe, P. C.: Neurotransmitter abnormalities in genetically epileptic rodents. Fed. Proc. 43: 2505–2509, 1984.

    PubMed  CAS  Google Scholar 

  • Laird II, H. E., Hadjicostantinou, M., and Neff, N. H.: Abnormalities in the central cholinergic transmitter system of the genetically epilepsy prone rat. Life Sci. 39(9): 783–787, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Laird II, H. E. and Huxtable, R. J.: Effect of Taurine on Audiogenic Seizure Response in Rats, In: Taurine (R. Huxtable and A. Barbeau, eds.) Raven, New York, 1976.

    Google Scholar 

  • Laird, H. E. and Huxtable, R.: Taurine and Audiogenic Epilepsy, In: Taurine and Neurological Disorders (A. Barbeau and R. J. Huxtable, eds.) Raven, New York, 1978.

    Google Scholar 

  • Lazarewicz, J. W., Noremberg, K., Lehmann, A., and Hamburger, A.: Effects of taurine on calcium binding and accumulation in rabbit hippocampal and cortical synaptosomes. Neurochem. Int. 7(8): 421–427, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Lehman, A.: Psychopharmacology of the Response to Noise, With Special Reference to Audiogenic Seizure in Mice, In: Physiological Effects of Noise (B. L. Welch and A. S. Welsch, eds.) Plenum, New York, 1970.

    Google Scholar 

  • Lehman, A. and Huxtable, R. J.: (Personal communications), 1985.

    Google Scholar 

  • McEachron, D. L., Jobe, P. C., Smith, W. K., Schlusselberg, D., Woodward, D. J., and Waterhouse, B. D.: 2-DG uptake patterns in the CNS of genetically epilepsy-prone rats: A computer facilitated analysis. Neurosci. Abst.10: 409, 1984.

    Google Scholar 

  • Michell, R. H.: Inositol phospholipid and cell surface receptor function. Biochem. Biophys. Acta 415: 81–147, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Miller, F. P., Cox, R. H., Snodgrass, W. R., and Maickel, R. P.: Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and

    Google Scholar 

  • p-chloro-N-methylamphetamine on rat brain, norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid. Biochem. Pharmacol. 19: 435–442, 1970.

    Article  Google Scholar 

  • Mills, S. A., Reigel, C. E., Jobe, P. C. and Savage, D. D.: Increase in the number of hippocampal (3H)-glutamate binding sites in rats inbred for a genetic predisposition to acoustic stimulus induced seizures. Neurosci. Abst. 11: 1315, 1985.

    Google Scholar 

  • Mimaki, T., Yabuuchi, H., Laird, H., and Yamamura, H. I.: Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain. Ped. Pharmacol. 4: 205–211, 1984.

    CAS  Google Scholar 

  • Nicoletti, F., Barbaccia, M. L., Iadarola, M., Pozzi, O., and Laird II., H. E.: Abnormality of alpha-1 adrenergic receptors in the frontal cortex of epileptic rats. J. Neurochem. 46: 270–273, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Nishizuka, Y.: Turnover of inositol phospholipids and signal transduction. Science 225: 1365–1370, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Pfeifer, A. K. and Galambos, E.: The effect of d1-p-chloroamphetamine on the susceptibility to seizures and on the monoamine level in brain and heart of mice and rats. J. Pharm. Pharmacol. 19: 400–402, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Picchioni, A., Chin, L., Choisser, D., and Breitner, C.: 5-Hydroxytryptamine (5-HT) and norepinephrine (NE): Relationship to audiogenic seizure. Pharmacologist 5: 238, 1963.

    Google Scholar 

  • Pletscher, A., Da Prada, M., and Burkard, W. P.: The Effect of Substituted Phenylethylamines on the Metabolism of Biogenic Monoamines, In: International Symposium on Amphetamines and Related Compounds, (E. Costa and S. Garattini, eds.) Raven, New York, 1970.

    Google Scholar 

  • Reigel, C. E., Jobe, P. C., Woods, T. W., and Dailey, J. W.: A GABAergic convulsant profile in the genetically epilepsy-prone rat. Neurosci. Abst.10: 408, 1984.

    Google Scholar 

  • Reigel, C. E., Jr., Stewart, J. J., Rinaudo, J. W., Dailey, J. W., and Jobe, P. C.: Extraordinary small doses of intracerebroventricular morphine produces tonic extensor convulsions in the genetically epilepsyprone rat. Fed. Proc. 44: 1106, 1985.

    Google Scholar 

  • Roberts, R. C., Ribak, C. E., Peterson, G. M., and Oertel, W. H.: Increased numbers of GABAergic neurons in the inferior colliculus of the genetically epilepsy-prone rat. Neurosci. Abst. 10: 410, 1984.

    Google Scholar 

  • Roth, B. L., Nakaki, T., Chuang, D.-M., and Costa, E.: Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover. Neuropharmacol. 23: 12231225, 1984.

    Google Scholar 

  • Rudzik, A. D. and Johnson, G. A.: Effect of Amphetamine and Amphetamine Analogs on Convulsive Thresholds, In: International Symposium on Amphetamines and Related Compounds (E. Costa and S. Garrattini, eds.) Raven, New York, 1970.

    Google Scholar 

  • Savage, D. D., Reigel, C. E., and Jobe, P. C.: The development of angular bundle kindled seizures is accelerated in rats with a genetic predisposition to audiogenic seizures. Neurosci. Abst. 10: 1319, 1985.

    Google Scholar 

  • Sokoloff, L., Reivich, M., Kennedy, C., Desrosiers, M. H., Patlak, C. S., Pettigrew, K. D., Sakurada, O., and Shinohara, M.: The (14-C)deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28: 897–916, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Speth, R., Laird II, H. E., and Yamamura, H. I.: Unpublished observations, 1979.

    Google Scholar 

  • Stewart, J. J., Rinaudo, J. D., Reigel, C. E., Jobe, P. C., and Dailey, J. W.: Intracerebroventricular morphine produces convulsions in genetically epilepsy-prone rats. Neurosci. Abst.10: 408, 1984.

    Google Scholar 

  • Tacke, U. and Braestrup, C.: A study on benzodiazepine receptor binding in audiogenic seizure-susceptible rats. Acta Pharmacol. Toxicol. 55: 252–259, 1984.

    Article  CAS  Google Scholar 

  • Tower, D. A.: GABA and Seizures: Clinical Correlates in Man, In: GABA in Nervous System Function (E. Roberts, T. N. Chase, and D. B. Tower, eds.) Raven, New York, 1976.

    Google Scholar 

  • Waterhouse, B. D., McEachron, D. L., and Woodward, D. J.: Personal communications, 1985.

    Google Scholar 

  • Waters, S.: Serotonin receptor binding: Characterization of serotonin-1 receptor subpopulations and determination of the effect of neurotoxic chemicals on ligand binding interaction. (Masters thesis). Tucson, University of Arizona, 1983.

    Google Scholar 

  • Wood, J. D.: The role of gamma-aminobutyric acid in the mechanism of seizures. Prog. Neurobiol. 5: 77–95, 1975.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Hugh E. Laird II
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  2. Phillip C. Jobe
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Editors and Affiliations

  1. Department of Basic Sciences, College of Medicine at Peoria, University of Illinois, Peoria, Illinois, USA

    Phillip C. Jobe

  2. Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

    Hugh E. Laird II

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Laird, H.E., Jobe, P.C. (1987). The Genetically Epilepsy-Prone Rat. In: Jobe, P.C., Laird, H.E. (eds) Neurotransmitters and Epilepsy. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-462-7_4

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  • DOI: https://doi.org/10.1007/978-1-59259-462-7_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5982-2

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