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Experimental Psychopharmacology pp 341–391Cite as

Aversive Stimulus Properties of Drugs

The Conditioned Taste Aversion Paradigm

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Abstract

The majority of psychoactive drugs induce conditioned taste aversion (CTA). The basic CTA procedure usually involves pairing ingestion of a novel-tasting fluid with drug injection. Following recovery from the drug studied, subjects are again presented with the novel fluid. Acquisition of CTA is assessed in terms of either a reduced intake of the fluid relative to the preconditioning base-line, or a reduced preference for the drug-paired fluid in a choice procedure. Almost universally, reductions in intake of drug-paired substances have been assumed to be a result of the development of an association between some aversive stimulus property of the drug and the taste of the novel fluid—this being the derivation of the term “conditioned taste aversion.” However, as argued elsewhere (Goudie, 1979) and discussed below, some conditioned taste aversions may be misnamed phenomena, and there may be little justification for assuming that they involve aversive stimulus properties of drugs (see also Stolerman and D’Mello, 1981).

Keywords

  • Taste Aversion
  • Conditioned Taste Aversion
  • Conditioned Aversion
  • Area Postrema
  • Food Aversion

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors
  1. Andrew J. Goudie
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  1. Psychiatric Research Division, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Andrew J. Greenshaw & Colin T. Dourish & 

  2. Merck, Sharpe, & Dohme Research Laboratories, Neuroscience Centre, Harlow, UK

    Colin T. Dourish

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Goudie, A.J. (1987). Aversive Stimulus Properties of Drugs. In: Greenshaw, A.J., Dourish, C.T. (eds) Experimental Psychopharmacology. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-461-0_8

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