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Hereditary Breast Cancer Genes

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Breast Cancer

Part of the book series: Contemporary Cancer Research ((CCR))

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Abstract

Most breast cancers arise in women without a family history of the disease. However, in 5–10% of cases, or 25% of cases diagnosed before age 30 yr, an inherited predisposition is proposed. As long ago as 1866, Paul Broca documented aggregation of breast cancer in certain families. In 1978, Lynch et al. (1) described 86 families with a high incidence of breast cancer. Twelve families also had ovarian cancer, and there was evidence for a highly penetrant dominant gene predisposing to either type of cancer. Many of these families also had cancers at other sites and individuals with two or more primary cancers.

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Authors
  1. Lynda B. Bennett
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  2. Joel D. Taurog
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  3. Anne M. Bowcock
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  1. Department of Pediatrics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Anne M. Bowcock

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Bennett, L.B., Taurog, J.D., Bowcock, A.M. (1999). Hereditary Breast Cancer Genes. In: Bowcock, A.M. (eds) Breast Cancer. Contemporary Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-456-6_9

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  • DOI: https://doi.org/10.1007/978-1-59259-456-6_9

  • Publisher Name: Humana Press, Totowa, NJ

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