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Magnetic Resonance Imaging (MRI) and MRI-Guided Intervention in the Detection and Diagnosis of Breast Cancer

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Image-Guided Diagnosis and Treatment of Cancer

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Abstract

As clinical investigation into the utility of magnetic resonance imaging (MRI) as a breast-imaging tool continues, there is now a large body of evidence demonstrating the increased sensitivity of MRI in the detection of breast cancer compared with conventional imaging methods, with reported sensitivities for the visualization of invasive breast cancer approaching 100% (1–5). The reported sensitivities of MRI for the visualization of ductal carcinoma in situ (DCIS) have been more variable, ranging from 40 to 100% (6–10). It has been demonstrated that not only can MRI visualize breast cancer but mammographically, sonographically, and clinically occult breast cancer, both invasive cancer and DCIS, as well. MRI has been shown to be more accurate than mammography and ultrasound in determining the size of the primary breast cancer and in the detection of multifocal, multicentric, and bilateral breast cancer (11–18). In addition to these studies, which have evaluated MRI in the diagnostic setting, there are now reports of MRI-detected breast cancer in the screening setting, specifically in the evaluation of women at high risk for the development of breast cancer (19–21).

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References

  1. Heywang SH, Wolf A, Pruss E, et al. MR imaging of the breast with Gd-DTPA: use and limitations. Radiology 1989;171:95–103.

    PubMed  CAS  Google Scholar 

  2. Kaiser WA, Zeitler E. MR imaging of the breast: fast imaging sequences with and without Gd-DTPA. Preliminary observations. Radiology 1989;170:681–686.

    PubMed  CAS  Google Scholar 

  3. Harms SE, Flamig DP, Hensley KL, et al. MR imaging of the breast with rotating delivery of excitation off resonance: clinical experience with pathologic correlation. Radiology 1993;187:493–501.

    PubMed  CAS  Google Scholar 

  4. Boetes C, Barentsz JO, Mus RD, et al. MR characterization of suspicious breast lesions with a gadolinium-enhanced turboflash subtraction technique. Radiology 1994;193:777–781.

    PubMed  CAS  Google Scholar 

  5. Gilles R, Guinebretiere JM, Lucidarme O, et al. Nonpalpable breast tumors: diagnosis with contrast-enhanced subtraction dynamic MR imaging. Radiology 1994;191:625–631.

    PubMed  CAS  Google Scholar 

  6. Soderstrom CE, Harms SE, Copit DS, et al. Three-dimensional RODEO breast MR imaging of lesions containing ductal carcinoma in situ. Radiology 1996;201:427–432.

    PubMed  CAS  Google Scholar 

  7. Gilles R, Zafrani B, Guinebretiere JM, et al. Ductal carcinoma in situ: MR imaging-histopathologic correlation. Radiology 1995;196:415–419.

    PubMed  CAS  Google Scholar 

  8. Piccoli CW, Matteucci T, Outwater EK, Siegelman ES, Mitchell DG. Breast cancer diagnosis with MR imaging: effect of clinical and mammographic findings on recommendations for biopsy. Radiology 1995;196:415–419.

    Google Scholar 

  9. Westerhof JP, Fischer U, Moritz JD, Oestmann JW. MR imaging of mammographically detected clustered microcalcifications: is there any value? Radiology 1998;207:675–681.

    PubMed  CAS  Google Scholar 

  10. Gilles R, Zafrani B, Guinebretiere JM, et al. Ductal carcinoma in situ: MR imaging-histopathologic correlation. Radiology 1995;196:415–419.

    PubMed  CAS  Google Scholar 

  11. Orel SG, Mendonca MH, Reynolds C, Schnall MD, Solin LJ, et al. MR imaging of ductal carcinoma in situ. Radiology 1997;202:413–420.

    PubMed  CAS  Google Scholar 

  12. Orel SG, Schnall MD, Newman RW, et al. MR imaging-guided localization and biopsy of breast lesions: Initial experience. Radiology 1994;193:97–102.

    PubMed  CAS  Google Scholar 

  13. Rodenko GN, Harms SE, Pruneda JM, et al. MR imaging in the management before sur- gery of lobular carcinoma of the breast: correlation with pathology. Am J Roentgenol 1996;167:1415–1419.

    CAS  Google Scholar 

  14. Boetes C, Mus RD, Holland R, et al. Breast tumors: comparative accuracy of MR imaging relative to mammography and US for demonstrating extent. Radiology 1995;197:43–47.

    Google Scholar 

  15. Orel SG, Schnall MD, Powell CM, et al. Staging of suspected breast cancer: effect of MR imaging and MR-guided biopsy. Radiology 1995;196:115–122.

    PubMed  CAS  Google Scholar 

  16. Essermann L, Hylton N, Yassa L, Barclay J, Frankel S, et al. Utility of magnetic resonance imaging in the management of breast cancer: evidence for improved preoperative staging. J Clin Oncol 1999;17:110–119.

    Google Scholar 

  17. Fischer U, Kopka L, Grabbe E. Breast carcinoma: effect of preoperative contrast-enhanced MR imaging on the therapeutic approach. Radiology 1999;213:881–888.

    PubMed  CAS  Google Scholar 

  18. Mumtaz H, Hall-Craggs MA, Davidson T, et al. Staging of symptomatic primary breast cancer with MR imaging. Am J Roentgenol 1997;169:417–424.

    CAS  Google Scholar 

  19. Slantez PJ, Edmister WB, Yeh ED, et al. Occult contralateral breast carcinoma incidentally detected by breast magnetic resonance imaging. Breast J 2003;8(3):145–148.

    Article  Google Scholar 

  20. Lee S, Orel SG, Woo IJ, et al. MR imaging screening of the contralateral breast in patients with newly diagnosed breast cancer: preliminary results. Radiology 2003;226:773–778.

    Article  PubMed  Google Scholar 

  21. Kuhl CK, Schmutzer RK, Leutner CC, et al. Breast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary results. Radiology 2000;215:267–279.

    PubMed  CAS  Google Scholar 

  22. Hylton N. M. , Kinkel K. Technical aspects of breast magnetic resonance imaging, in Topics in Magnetic Resonance Imaging, Vol. 9 (Brant Zawadzki M, Edelman RR, and Mitchell DG, eds.) Lippincott-Raven, Philadelphia, 1998; pp. 3–16.

    Google Scholar 

  23. Orel SG, Schnall MD. MR imaging of the breast for the detection, diagnosis, and staging of breast cancer: state of the Art. Radiology 2001;220:13–30.

    PubMed  CAS  Google Scholar 

  24. Daniel BL, Butts K, Glover GH, Cooper C, Herfkens FJ. Breast cancer: gadolinium-enhanced MR imaging with a 0.5-T open imager and three-point dixon technique. Radiology 1998;207:183–190.

    PubMed  CAS  Google Scholar 

  25. Insko EK, Connick TJ, Schnall MD, Orel SG. Multicoil array for high resonance imaging of the breast. Magn Reson Med 1997;37:778–784.

    Article  PubMed  CAS  Google Scholar 

  26. Greenman RL, Lenkinski RE, Schnall MD. Bilateral imaging using separate interleaved 3D volumes and dynamically switched multiple receive coil arrays. Magn Reson Med 1998;39:108–115.

    Article  PubMed  CAS  Google Scholar 

  27. Foo T. K. F., Sawyer AM, Faulkner WH, et al. Inversion in the steady state: contrast optimization and reduced imaging time with fast three-dimensional inversion-recovery-prepared GRE pulse sequences. Radiology 1994;191:85–90.

    PubMed  CAS  Google Scholar 

  28. Fischer U, Vosshenrich R, Doler W, et al. MR imaging-guided breast intervention: experience with two systems. Radiology 1995;195:533–538.

    PubMed  CAS  Google Scholar 

  29. Heywang-Koebrunner SH, Halle MD, et al. Optimal procedure and coil design for MR imaging-guided transcutaneous needle localization and biopsy. Radiology 1994;193:267.

    Google Scholar 

  30. Kuhl CK, Elevelt A, Leutner CC, et al. Interventional breast MR imaging: clinical use of stereotactic localization and biopsy device. Radiology 1997;204:667–675.

    PubMed  CAS  Google Scholar 

  31. Daniel BL, Birdwell RL, Ikeda DM, et al. Breast lesion localization: a free-hand interactive MR imaging technique. Radiology 1998;207:455–463.

    PubMed  CAS  Google Scholar 

  32. Heywang-Koebrunner SH, Heinig A, Schauloeffel-Schulz U, et al. MR-percutaneous vacuum breast biopsy of breast lesions: initial experience with 100 lesions. Radiology (RSNA) 1999; 289.

    Google Scholar 

  33. Orel SG, Schnall MD, LiVolsi VA, Troupin RH. Suspicious breast lesions: MR imaging with radiologic-pathologic correlation. Radiology 1994;190:485–493.

    PubMed  CAS  Google Scholar 

  34. Kuhl CK, Bieling HB, Gieseke J, et al. Healthy premenopausal breast parenchyma in dynamic contrast-enhanced MR imaging of the breast: normal contrast medium enhancement and cyclical-phase dependency. Radiology 1997;203:137–144.

    PubMed  CAS  Google Scholar 

  35. Kuhl CK, Mielcareck P, Klaschik S, et al. Dynamic breast MR Imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology 1999;211:101–110.

    PubMed  CAS  Google Scholar 

  36. Stomper PC, Herman S, Klippenstein DL, et al. Suspect breast lesions: findings at dynamic gadolinium-enhanced MR imaging correlated with mammographic and pathologic features. Radiology 1995;197:387–395.

    PubMed  CAS  Google Scholar 

  37. Orel S. G. Differentiating benign from malignant enhancing lesions identified at MR imaging of the breast: are time-signal intensity curves an accurate predictor. Radiology 1999;211:5–7.

    PubMed  CAS  Google Scholar 

  38. Buadu LD, Murakami J, Murayama S, et al. Patterns of peripheral enhancement in breast masses: correlation of findings on contrast medium enhanced MRI with histologic features and tumor angiogenesis. J Comp Assist Tomogr 1997;21:421–430.

    Article  CAS  Google Scholar 

  39. Sherif H, Mahfouz AE, Oellinger H, et al. Peripheral washout sign on contrast-enhanced MR images of the breast. Radiology 1997;205:209–213.

    PubMed  CAS  Google Scholar 

  40. Nunes LW, Schnall MD, Orel SG, et al. Breast MR imaging: interpretation model. Radiology 1997;202:833–841.

    PubMed  CAS  Google Scholar 

  41. Nunes LW, Schnall MD, Siegelman ES, et al. Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast. Am J Roentgenol 1997;169:409–415.

    CAS  Google Scholar 

  42. Harms SE, ed. Technical report of the international working group on breast MRI. J Magn Reson Imaging 1999;10:978–1015.

    Google Scholar 

  43. Lee CH, Smith RC, Levine JA, Troiano RN, Tocino I. Clinical usefulness of MR imaging of the breast in the evaluation of the problematic mammogram. Am J Roentgenol 1999;173:1323–1329.

    CAS  Google Scholar 

  44. Orel S. G. High-resolution MR imaging for the detection, diagnosis, and staging of breast cancer. RadioGraphics 1998;18:903–912.

    PubMed  CAS  Google Scholar 

  45. Mumatz H, Davidson T, Hall-Craggs MA, et al. Comparison of magnetic resonance imaging and conventional triple assessment in locally recurrent breast cancer. Br J Surg 1997:84:1147–1151.

    Article  Google Scholar 

  46. Muuller RD, Barkhausen J, Sauerwein W, Langer R. Assessment of local recurrence after breast-conserving therapy with MRI. J Comput Assist Tomogr 1998;22:408–412

    Article  PubMed  CAS  Google Scholar 

  47. Solomon B, Orel SG, Reynolds C, Schnall MD. Delayed development of enhancement in fat necrosis after breast conservation therapy: a potential pitfall of MR imaging of the breast. Am J Roentgenol 1998;170:966–968.

    CAS  Google Scholar 

  48. Morris EA, Schwartz LH, Dershaw DD, et al. MR imaging of the breast in patients with occult primary breast carcinoma. Radiology 1997;205:437–440.

    PubMed  CAS  Google Scholar 

  49. Orel SG, Weinstein SP, Schnall MD, et al. Breast MR imaging in patients with axillary node metastases and unknown primary malignancy. Radiology 1999;212:543–549.

    PubMed  CAS  Google Scholar 

  50. Orel SG, Schnall MD, Powell CM, et al. Staging of suspected breast cancer: effect of MR imaging and MR-guided biopsy. Radiology 1995;196:115–122.

    PubMed  CAS  Google Scholar 

  51. Essermann L, Hylton N, Yassa L, et al. Utility of magnetic resonance imaging in the management of breast cancer: evidence for improved preoperative staging. J Clin Oncol 1999;17:110–119.

    Google Scholar 

  52. Fischer U, Kopka L, Grabbe E. Breast carcinoma: effect of preoperative contrast-enhanced MR imaging on the therapeutic approach. Radiology 1999;213:881–888.

    PubMed  CAS  Google Scholar 

  53. Mumtaz H, Hall-Craggs MA, Davidson T, et al. Staging of symptomatic primary breast cancer with MR imaging. AJR Am J Roentgenol 1997;169:417–424.

    PubMed  CAS  Google Scholar 

  54. Orel SG, Reynolds C, Schnall MD. Breast carcinoma: MR imaging before re-excisional biopsy. Radiology 1997;205:429–436.

    PubMed  CAS  Google Scholar 

  55. Soderstrom CE, Harms SE, Farrell RS, Pruneda JM, Flamig DP. Detection with MR imaging of residual tumor in the breast soon after surgery. Am JRoentgenol 1997;168:485–488.

    CAS  Google Scholar 

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Authors
  1. Susan Greenstein Orel MD
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Editors and Affiliations

  1. Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

    Anthony V. D’Amico MD, PhD  & Jay R. Harris MD  & 

  2. Massachusetts General Hospital, Harvard Medical Hospital, Boston, MA, USA

    Jay S. Loeffler MD

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© 2003 Humana Press Inc. Totowa, NJ

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Orel, S.G. (2003). Magnetic Resonance Imaging (MRI) and MRI-Guided Intervention in the Detection and Diagnosis of Breast Cancer. In: D’Amico, A.V., Loeffler, J.S., Harris, J.R. (eds) Image-Guided Diagnosis and Treatment of Cancer. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-422-1_4

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  • DOI: https://doi.org/10.1007/978-1-59259-422-1_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-368-8

  • Online ISBN: 978-1-59259-422-1

  • eBook Packages: Springer Book Archive

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